Ru(II)-Catalyzed C–H Aminocarbonylation of N‑(Hetero)aryl-7-azaindoles with Isocyanates

Ru(II)-Catalyzed C–H Aminocarbonylation of N‑(Hetero)aryl-7-azaindoles with Isocyanates

The ruthenium­(II)-catalyzed C–H aminocarbonylation of N-(hetero)­aryl-7-azaindoles with isocyanates is described. The excellent site selectivity at the ortho-position within the N-(hetero)­aryl ring was observed to provide ortho-amidated N-(hetero)­aryl-7-azaindoles under the mild reaction conditio...

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Veröffentlicht in:Journal of organic chemistry 2018-04, Vol.83 (8), p.4641-4649
Hauptverfasser: Jeong, Taejoo, Lee, Suk Hun, Chun, Rina, Han, Sangil, Han, Sang Hoon, Jeon, Yeong Uk, Park, Jihye, Yoshimitsu, Takehiko, Mishra, Neeraj Kumar, Kim, In Su
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container_end_page 4649
container_issue 8
container_start_page 4641
container_title Journal of organic chemistry
container_volume 83
creator Jeong, Taejoo
Lee, Suk Hun
Chun, Rina
Han, Sangil
Han, Sang Hoon
Jeon, Yeong Uk
Park, Jihye
Yoshimitsu, Takehiko
Mishra, Neeraj Kumar
Kim, In Su
description The ruthenium­(II)-catalyzed C–H aminocarbonylation of N-(hetero)­aryl-7-azaindoles with isocyanates is described. The excellent site selectivity at the ortho-position within the N-(hetero)­aryl ring was observed to provide ortho-amidated N-(hetero)­aryl-7-azaindoles under the mild reaction conditions. The resulting 7-azaindole derivatives can be readily transformed into 7-azaindoles containing carboxylic acid and alkyl amine functional groups.
doi_str_mv 10.1021/acs.joc.8b00388
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title Ru(II)-Catalyzed C–H Aminocarbonylation of N‑(Hetero)aryl-7-azaindoles with Isocyanates
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