Ru(II)-Catalyzed C–H Aminocarbonylation of N‑(Hetero)aryl-7-azaindoles with Isocyanates

Ru(II)-Catalyzed C–H Aminocarbonylation of N‑(Hetero)aryl-7-azaindoles with Isocyanates

The ruthenium­(II)-catalyzed C–H aminocarbonylation of N-(hetero)­aryl-7-azaindoles with isocyanates is described. The excellent site selectivity at the ortho-position within the N-(hetero)­aryl ring was observed to provide ortho-amidated N-(hetero)­aryl-7-azaindoles under the mild reaction conditio...

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Veröffentlicht in:Journal of organic chemistry 2018-04, Vol.83 (8), p.4641-4649
Hauptverfasser: Jeong, Taejoo, Lee, Suk Hun, Chun, Rina, Han, Sangil, Han, Sang Hoon, Jeon, Yeong Uk, Park, Jihye, Yoshimitsu, Takehiko, Mishra, Neeraj Kumar, Kim, In Su
Format: Artikel
Sprache:eng
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Zusammenfassung:The ruthenium­(II)-catalyzed C–H aminocarbonylation of N-(hetero)­aryl-7-azaindoles with isocyanates is described. The excellent site selectivity at the ortho-position within the N-(hetero)­aryl ring was observed to provide ortho-amidated N-(hetero)­aryl-7-azaindoles under the mild reaction conditions. The resulting 7-azaindole derivatives can be readily transformed into 7-azaindoles containing carboxylic acid and alkyl amine functional groups.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.8b00388