Griseusin D, a New Pyranonaphthoquinone Derivative from a Alkaphilic Nocardiopsis sp

A new pyranonaphthoquinone antibiotic, griseusin D ( 1 ) was isolated from the cultural fluid of the alkaphilic Nocardiopsis sp. The structure was determined as 5′-one-4-hydroxy-12-methoxygriseusin by spectroscopic methods, comparison with reported data and single-crystal X-ray analysis. 1 displayed...

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Veröffentlicht in:	Journal of antibiotics 2007-12, Vol.60 (12), p.757-761
Hauptverfasser:	Li, Yi-Qing, Li, Ming-Gang, Li, Wei, Zhao, Jiang-Yuan, Ding, Zhang-Gui, Cui, Xiao-Long, Wen, Meng-Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycetales - metabolism Alternaria Alternaria - drug effects Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - pharmacology Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Cell Line, Tumor Crystallography, X-Ray Culture Media - chemistry Cytotoxicity Humans Inhibitory Concentration 50 Leukemia Life Sciences Medicinal Chemistry Microbial Sensitivity Tests Microbiology Molecular Structure Naphthoquinones - chemistry Naphthoquinones - isolation & purification Naphthoquinones - pharmacology Nocardiopsis Organic Chemistry Spectrum Analysis
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Zusammenfassung:	A new pyranonaphthoquinone antibiotic, griseusin D ( 1 ) was isolated from the cultural fluid of the alkaphilic Nocardiopsis sp. The structure was determined as 5′-one-4-hydroxy-12-methoxygriseusin by spectroscopic methods, comparison with reported data and single-crystal X-ray analysis. 1 displayed strong cytotoxicity against human leukemia cells (HL60) and modest cytotoxicity against human lung adenocarcinoma cell lines (AGZY) with IC 50 values of 0.23 and 19.6 μg/ml, respectively. It also exhibited weak antifungal activity against Alternaria alternate with MIC of 140 μg/ml.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/ja.2007.100