Palladium-Catalyzed Regioselective C8–H Amination of 1‑Naphthylamine Derivatives with Aliphatic Amines

Palladium-Catalyzed Regioselective C8–H Amination of 1‑Naphthylamine Derivatives with Aliphatic Amines

A simple and facile protocol for palladium-catalyzed picolinamide-directed C8–H amination of 1-naphthylamine derivatives with simple secondary aliphatic amines was developed, thereby providing a new route to 1,8-naphthalenediamine derivatives. It is noteworthy that the picolinamide moiety as a biden...

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Veröffentlicht in:Organic letters 2016-09, Vol.18 (18), p.4594-4597
Hauptverfasser: Li, Zexian, Sun, Suyan, Qiao, Huijie, Yang, Fan, Zhu, Yu, Kang, Jianxun, Wu, Yusheng, Wu, Yangjie
Format: Artikel
Sprache:eng
Schlagworte:
amination
amines
catalytic activity
moieties
palladium
regioselectivity
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Zusammenfassung:A simple and facile protocol for palladium-catalyzed picolinamide-directed C8–H amination of 1-naphthylamine derivatives with simple secondary aliphatic amines was developed, thereby providing a new route to 1,8-naphthalenediamine derivatives. It is noteworthy that the picolinamide moiety as a bidentate directing group may play a key role in this regioselective transformation.
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/acs.orglett.6b02243