Disease Modification for Parkinson's Disease: Axonal Regeneration and Trophic Factors

Disease Modification for Parkinson's Disease: Axonal Regeneration and Trophic Factors

ABSTRACT Disease modification and structural neuroprotection have been the holy grail for Parkinson's disease (PD) experimental therapeutics. Theoretically, there are a number of ways to implement such therapeutics, but to date all have failed. This review examines the potential of axonal regen...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Movement disorders 2018-05, Vol.33 (5), p.678-683
Hauptverfasser: Kordower, Jeffrey H., Burke, Robert E.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
axons
Axons - drug effects
Disease Models, Animal
Disease modification
Humans
Intercellular Signaling Peptides and Proteins - metabolism
Movement disorders
Neurodegenerative diseases
Neuroprotection
Neuroprotective Agents - therapeutic use
Parkinson Disease - therapy
Parkinson's disease
Regeneration
Regeneration - drug effects
Trophic Factors
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:ABSTRACT Disease modification and structural neuroprotection have been the holy grail for Parkinson's disease (PD) experimental therapeutics. Theoretically, there are a number of ways to implement such therapeutics, but to date all have failed. This review examines the potential of axonal regeneration and trophic factor delivery for the nigrostriatal system as 2 such approaches that historically have initiated much excitement. However, we conclude this discussion with the following question: has science passed these approaches by? © 2018 International Parkinson and Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.27383