Light‐Controlled Simultaneous “On Demand” Release of Cytotoxic Combinations for Bimodal Killing of Cancer Cells

Light‐Controlled Simultaneous “On Demand” Release of Cytotoxic Combinations for Bimodal Killing of Cancer Cells

In this contribution, we report a novel entirely photocontrolled nanoplatform comprising a binary mixture of pluronic copolymers capable of self‐assembling into core–shell micelles and co‐entrapping two photoactivatable components: a benzoporphyrin photosensitizer for photodynamic therapy (PDT) and...

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Veröffentlicht in:Chemistry : a European journal 2018-05, Vol.24 (30), p.7664-7670
Hauptverfasser: Tessaro, André Luiz, Fraix, Aurore, Failla, Mariacristina, Cardile, Venera, Graziano, Adriana C. E., Estevão, Bianca Martins, Rescifina, Antonio, Sortino, Salvatore
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma
Anticancer properties
Antitumor activity
Assembling
Chemistry
chemotherapy
Chlorambucil
Coumarin
Cytotoxicity
micelles
multimodal therapy
Photochemicals
Photodynamic therapy
Polydispersity
Preservation
Singlet oxygen
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Zusammenfassung:In this contribution, we report a novel entirely photocontrolled nanoplatform comprising a binary mixture of pluronic copolymers capable of self‐assembling into core–shell micelles and co‐entrapping two photoactivatable components: a benzoporphyrin photosensitizer for photodynamic therapy (PDT) and coumarin‐photocaged chemotherapeutic agent Chlorambucil (CAB). The resulting supramolecular micellar assembly is about 30 nm in diameter with a polydispersity index
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201800862