Effects of caffeine on the preterm brain: An observational study

Effects of caffeine on the preterm brain: An observational study

Caffeine improves neurodevelopmental outcome of preterm infants. This study analyses the effects of caffeine on the neonatal brain. We hypothesized that caffeine has a neuroprotective effect through an increase in oxygen metabolism; reflected by increased cerebral oxygen extraction, electrical funct...

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Veröffentlicht in:Early human development 2018-05, Vol.120, p.17-20
Hauptverfasser: Dix, Laura M.L., van Bel, Frank, Baerts, Willem, Lemmers, Petra M.A.
Format: Artikel
Sprache:eng
Schlagworte:
Apnea - prevention & control
Brain - diagnostic imaging
Brain - drug effects
Brain - physiology
Caffeine
Caffeine - administration & dosage
Caffeine - pharmacology
Cerebral oxygenation
Cerebral perfusion
Electroencephalogram
Electroencephalography
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - prevention & control
Near-infrared spectroscopy
Neuroprotective Agents - administration & dosage
Neuroprotective Agents - pharmacology
Oxygen - metabolism
Spectroscopy, Near-Infrared
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Zusammenfassung:Caffeine improves neurodevelopmental outcome of preterm infants. This study analyses the effects of caffeine on the neonatal brain. We hypothesized that caffeine has a neuroprotective effect through an increase in oxygen metabolism; reflected by increased cerebral oxygen extraction, electrical function, and perfusion. Preterm infants
ISSN:0378-3782
1872-6232
DOI:10.1016/j.earlhumdev.2018.03.008