Why validation of prognostic models matters?

Why validation of prognostic models matters?

Prognostic models are powerful tools for treatment personalisation. However, not all proposed models work well when validated using new data, despite impressive results being reported initially. Here, we will use a hands-on approach to highlight important aspects of prognostic modelling, as well as...

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Veröffentlicht in:Radiotherapy and oncology 2018-06, Vol.127 (3), p.370-373
Hauptverfasser: Zwanenburg, Alex, Löck, Steffen
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers
Prognostic models
TRIPOD
Validation
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Beschreibung
Zusammenfassung:Prognostic models are powerful tools for treatment personalisation. However, not all proposed models work well when validated using new data, despite impressive results being reported initially. Here, we will use a hands-on approach to highlight important aspects of prognostic modelling, as well as to demonstrate methods to generate generalisable models.
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2018.03.004