Iontophoresis: A non-invasive ocular drug delivery

Iontophoresis as a non-invasive technique for ocular drug delivery has been investigated for many years. This paper provides an overview of the approaches currently used in the development of the ocular iontophoretic device, the essential features of this procedure and the reported toxicity. This re...

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Veröffentlicht in:	Journal of controlled release 2006-02, Vol.110 (3), p.479-489
Hauptverfasser:	Eljarrat-Binstock, Esther, Domb, Abraham J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Biological and medical sciences Drug Delivery Systems - methods Eye Eye - drug effects Eye - metabolism Eye Diseases - drug therapy Eye Diseases - metabolism General pharmacology Humans Hydrogel Iontophoresis Iontophoresis - methods Medical sciences Ocular delivery Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments
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Zusammenfassung:	Iontophoresis as a non-invasive technique for ocular drug delivery has been investigated for many years. This paper provides an overview of the approaches currently used in the development of the ocular iontophoretic device, the essential features of this procedure and the reported toxicity. This review focuses on the experimental results after transcorneal and transscleral iontophoresis of different drugs, emphasizing the current density applied and the treatment duration used by the investigators.
ISSN:	0168-3659 1873-4995
DOI:	10.1016/j.jconrel.2005.09.049