Discovery and optimization of a novel Neuromedin B receptor antagonist

The discovery and parallel synthesis of potent, small molecule antagonists of Neuromedin B receptor based on the ary-hexahydro-dibenzodiazepin-1-one core is described. The discovery and parallel synthesis of potent, small molecule antagonists of Neuromedin B receptor based on the ary-hexahydro-diben...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2009-08, Vol.19 (15), p.4264-4267
Hauptverfasser:	Fu, Jiasheng, Shuttleworth, Stephen J., Connors, Richard V., Chai, Anne, Coward, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antagonist Ary-hexahydro-dibenzodiazepin-1-one Benzodiazepinones - chemical synthesis Benzodiazepinones - pharmacology Biological and medical sciences Chemistry, Pharmaceutical - methods Dose-Response Relationship, Drug Drug Design Electrons Gastrin-Releasing Peptide - chemistry HeLa Cells Humans Inhibitory Concentration 50 Ligands Medical sciences Models, Chemical Neuropharmacology Neurotransmitters. Neurotransmission. Receptors NMBR Parallel synthesis Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Peptides - chemistry Pharmacology. Drug treatments Receptors, Bombesin - antagonists & inhibitors Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The discovery and parallel synthesis of potent, small molecule antagonists of Neuromedin B receptor based on the ary-hexahydro-dibenzodiazepin-1-one core is described. The discovery and parallel synthesis of potent, small molecule antagonists of Neuromedin B receptor based on the ary-hexahydro-dibenzodiazepin-1-one core is described.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2009.05.124