Effect of Levosimendan on Renal Outcome in Cardiac Surgery Patients With Chronic Kidney Disease and Perioperative Cardiovascular Dysfunction: A Substudy of a Multicenter Randomized Trial

Acute kidney injury (AKI) occurs frequently after cardiac surgery. Levosimendan might reduce the incidence of AKI in patients undergoing cardiac surgery. The authors investigated whether levosimendan administration could reduce AKI incidence in a high-risk cardiac surgical population. Post hoc analy...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cardiothoracic and vascular anesthesia 2018-10, Vol.32 (5), p.2152-2159
Hauptverfasser:	Zangrillo, Alberto, Alvaro, Gabriele, Belletti, Alessandro, Pisano, Antonio, Brazzi, Luca, Calabrò, Maria G., Guarracino, Fabio, Bove, Tiziana, Grigoryev, Evgeny V., Monaco, Fabrizio, Boboshko, Vladimir A., Likhvantsev, Valery V., Scandroglio, Anna M., Paternoster, Gianluca, Lembo, Rosalba, Frassoni, Samuele, Comis, Marco, Pasyuga, Vadim V., Navalesi, Paolo, Lomivorotov, Vladimir V.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute kidney injury Acute Kidney Injury - epidemiology Acute Kidney Injury - etiology Acute Kidney Injury - prevention & control Aged Brazil - epidemiology cardiac surgery Cardiac Surgical Procedures - adverse effects Cardiotonic Agents - administration & dosage chronic kidney disease Dose-Response Relationship, Drug Double-Blind Method Female Glomerular Filtration Rate - drug effects Heart Valve Diseases - complications Heart Valve Diseases - surgery hemodynamic support Humans Incidence inotropes Italy - epidemiology levosimendan low cardiac output syndrome Male Middle Aged Mitral Valve - surgery Perioperative Period Postoperative Complications - epidemiology Postoperative Complications - etiology Postoperative Complications - prevention & control Renal Insufficiency, Chronic Russia - epidemiology Simendan - administration & dosage Treatment Outcome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Acute kidney injury (AKI) occurs frequently after cardiac surgery. Levosimendan might reduce the incidence of AKI in patients undergoing cardiac surgery. The authors investigated whether levosimendan administration could reduce AKI incidence in a high-risk cardiac surgical population. Post hoc analysis of a multicenter randomized trial. Cardiac surgery operating rooms and intensive care units of 14 centers in 3 countries. The study comprised 90 patients who underwent mitral valve surgery with an estimated glomerular filtration rate
ISSN:	1053-0770 1532-8422
DOI:	10.1053/j.jvca.2018.02.039