Body mass index, abdominal fatness, and hypertension incidence: a dose-response meta-analysis of prospective studies
Despite the established relationship of obesity to hypertension, the question as to whether there is a linear association between these two morbidities is unanswered. To quantitatively evaluate the relationship between obesity and hypertension, we carried out a dose–response meta-analysis of studies...
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| Veröffentlicht in: | Journal of human hypertension 2018-05, Vol.32 (5), p.321-333 |
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| creator | Zhou, Wen Shi, Yuanyuan Li, Yu-qian Ping, Zhiguang Wang, Chongjian Liu, Xuejiao Lu, Jie Mao, Zhen-xing Zhao, Jingzhi Yin, Lei Zhang, Dongdong Tian, Zhongyan Zhang, Lulu Li, Linlin |
| description | Despite the established relationship of obesity to hypertension, the question as to whether there is a linear association between these two morbidities is unanswered. To quantitatively evaluate the relationship between obesity and hypertension, we carried out a dose–response meta-analysis of studies that looked at the relationship of different adiposity measures to hypertension. We searched PubMed, Embase, and Web of Science databases for articles published before 27 June 2017. A random-effects model was used to pool relative risks and 95% confidence intervals. Restricted cubic spline analysis was used to model the relationship. A total of 59 studies were included. Fifty-seven cohort studies with 125,071 incident cases among 830,685 participants were included in the analysis of body mass index and hypertension with the summary relative risk for per 5-unit increment in body mass index of 1.50 (95% confidence interval: 1.40–1.59). We found that the risk of hypertension in the body mass index analysis was greater in populations where the baseline body mass index was |
| doi_str_mv | 10.1038/s41371-018-0046-1 |
| format | Article |
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2
. The summary relative risk for a 10-cm increase in waist circumference was 1.25 (95% confidence interval: 1.19–1.32) and per 0.1-unit increase in waist-to-hip ratio was 1.27 (95% confidence interval: 1.18–1.37). This meta-analysis suggests that in normal range of obesity indexes, as lean as possible may be the best suggestion to prevent hypertension incidence.</description><identifier>ISSN: 0950-9240</identifier><identifier>EISSN: 1476-5527</identifier><identifier>DOI: 10.1038/s41371-018-0046-1</identifier><identifier>PMID: 29581553</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/443/592/75/243 ; 692/700/459/1748 ; Adipose tissue ; Adipose tissues ; Body Mass Index ; Cardiovascular research ; Epidemiology ; Health Administration ; Health aspects ; Health risk assessment ; Hip ; Humans ; Hypertension ; Hypertension - epidemiology ; Hypertension - etiology ; Incidence ; Medicine ; Medicine & Public Health ; Meta-analysis ; Obesity ; Obesity - complications ; Obesity - diagnosis ; Prospective Studies ; Public Health ; Review Article ; Risk assessment ; Risk factors ; Waist Circumference ; Waist-Hip Ratio</subject><ispartof>Journal of human hypertension, 2018-05, Vol.32 (5), p.321-333</ispartof><rights>Macmillan Publishers Limited, part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-30cbee07280352b2e778ae16e806bafb948cb7bb567448297a00881c86c9b9e53</citedby><cites>FETCH-LOGICAL-c470t-30cbee07280352b2e778ae16e806bafb948cb7bb567448297a00881c86c9b9e53</cites><orcidid>0000-0001-5091-6621 ; 0000-0001-7076-2594</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41371-018-0046-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41371-018-0046-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29581553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Wen</creatorcontrib><creatorcontrib>Shi, Yuanyuan</creatorcontrib><creatorcontrib>Li, Yu-qian</creatorcontrib><creatorcontrib>Ping, Zhiguang</creatorcontrib><creatorcontrib>Wang, Chongjian</creatorcontrib><creatorcontrib>Liu, Xuejiao</creatorcontrib><creatorcontrib>Lu, Jie</creatorcontrib><creatorcontrib>Mao, Zhen-xing</creatorcontrib><creatorcontrib>Zhao, Jingzhi</creatorcontrib><creatorcontrib>Yin, Lei</creatorcontrib><creatorcontrib>Zhang, Dongdong</creatorcontrib><creatorcontrib>Tian, Zhongyan</creatorcontrib><creatorcontrib>Zhang, Lulu</creatorcontrib><creatorcontrib>Li, Linlin</creatorcontrib><title>Body mass index, abdominal fatness, and hypertension incidence: a dose-response meta-analysis of prospective studies</title><title>Journal of human hypertension</title><addtitle>J Hum Hypertens</addtitle><addtitle>J Hum Hypertens</addtitle><description>Despite the established relationship of obesity to hypertension, the question as to whether there is a linear association between these two morbidities is unanswered. To quantitatively evaluate the relationship between obesity and hypertension, we carried out a dose–response meta-analysis of studies that looked at the relationship of different adiposity measures to hypertension. We searched PubMed, Embase, and Web of Science databases for articles published before 27 June 2017. A random-effects model was used to pool relative risks and 95% confidence intervals. Restricted cubic spline analysis was used to model the relationship. A total of 59 studies were included. Fifty-seven cohort studies with 125,071 incident cases among 830,685 participants were included in the analysis of body mass index and hypertension with the summary relative risk for per 5-unit increment in body mass index of 1.50 (95% confidence interval: 1.40–1.59). We found that the risk of hypertension in the body mass index analysis was greater in populations where the baseline body mass index was <25 kg/m
2
. The summary relative risk for a 10-cm increase in waist circumference was 1.25 (95% confidence interval: 1.19–1.32) and per 0.1-unit increase in waist-to-hip ratio was 1.27 (95% confidence interval: 1.18–1.37). This meta-analysis suggests that in normal range of obesity indexes, as lean as possible may be the best suggestion to prevent hypertension incidence.</description><subject>631/443/592/75/243</subject><subject>692/700/459/1748</subject><subject>Adipose tissue</subject><subject>Adipose tissues</subject><subject>Body Mass Index</subject><subject>Cardiovascular research</subject><subject>Epidemiology</subject><subject>Health Administration</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Hip</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - epidemiology</subject><subject>Hypertension - etiology</subject><subject>Incidence</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meta-analysis</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - diagnosis</subject><subject>Prospective Studies</subject><subject>Public Health</subject><subject>Review Article</subject><subject>Risk assessment</subject><subject>Risk factors</subject><subject>Waist Circumference</subject><subject>Waist-Hip Ratio</subject><issn>0950-9240</issn><issn>1476-5527</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kl-L1TAQxYso7nX1A_giAUF8MGvSJk3q27r4DxZ80eeQpNO9WdqkdlLxfntT7uq6ouQhMPM7w5zhVNVTzs44a_RrFLxRnDKuKWOipfxeteNCtVTKWt2vdqyTjHa1YCfVI8Rrxramflid1J3UXMpmV-W3qT-QySKSEHv48YpY16cpRDuSweYIiKUUe7I_zLBkiBhSLKgPPUQPb4glfUKgC-CcIgKZIFtqi_yAAUkayLwknMHn8B0I5rUPgI-rB4MdEZ7c_KfV1_fvvlx8pJefP3y6OL-kXiiWacO8A2Cq1qyRtatBKW2Bt6BZ6-zgOqG9U87JVgmh605ZxrTmXre-cx3I5rR6eZxbdvi2AmYzBfQwjjZCWtHUjHdMyHKTgj7_C71O61JsbJTkrWg6Lm-pKzuCCXFIebF-G2rOpaqlVkK3hTr7B1VeD1PwKcIQSv2O4MUfgj3YMe8xjWsut8a7ID-CvhwVFxjMvITJLgfDmdkiYY6RMCUSZouE4UXz7MbZ6ibofyt-ZaAA9RHA0opXsNxa___Un4n-vyo</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Zhou, Wen</creator><creator>Shi, Yuanyuan</creator><creator>Li, Yu-qian</creator><creator>Ping, Zhiguang</creator><creator>Wang, Chongjian</creator><creator>Liu, Xuejiao</creator><creator>Lu, Jie</creator><creator>Mao, Zhen-xing</creator><creator>Zhao, Jingzhi</creator><creator>Yin, Lei</creator><creator>Zhang, Dongdong</creator><creator>Tian, Zhongyan</creator><creator>Zhang, Lulu</creator><creator>Li, Linlin</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5091-6621</orcidid><orcidid>https://orcid.org/0000-0001-7076-2594</orcidid></search><sort><creationdate>20180501</creationdate><title>Body mass index, abdominal fatness, and hypertension incidence: a dose-response meta-analysis of prospective studies</title><author>Zhou, Wen ; Shi, Yuanyuan ; Li, Yu-qian ; Ping, Zhiguang ; Wang, Chongjian ; Liu, Xuejiao ; Lu, Jie ; Mao, Zhen-xing ; Zhao, Jingzhi ; Yin, Lei ; Zhang, Dongdong ; Tian, Zhongyan ; Zhang, Lulu ; Li, Linlin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-30cbee07280352b2e778ae16e806bafb948cb7bb567448297a00881c86c9b9e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>631/443/592/75/243</topic><topic>692/700/459/1748</topic><topic>Adipose tissue</topic><topic>Adipose tissues</topic><topic>Body Mass Index</topic><topic>Cardiovascular research</topic><topic>Epidemiology</topic><topic>Health Administration</topic><topic>Health aspects</topic><topic>Health risk assessment</topic><topic>Hip</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - 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Academic</collection><jtitle>Journal of human hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Wen</au><au>Shi, Yuanyuan</au><au>Li, Yu-qian</au><au>Ping, Zhiguang</au><au>Wang, Chongjian</au><au>Liu, Xuejiao</au><au>Lu, Jie</au><au>Mao, Zhen-xing</au><au>Zhao, Jingzhi</au><au>Yin, Lei</au><au>Zhang, Dongdong</au><au>Tian, Zhongyan</au><au>Zhang, Lulu</au><au>Li, Linlin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body mass index, abdominal fatness, and hypertension incidence: a dose-response meta-analysis of prospective studies</atitle><jtitle>Journal of human hypertension</jtitle><stitle>J Hum Hypertens</stitle><addtitle>J Hum Hypertens</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>32</volume><issue>5</issue><spage>321</spage><epage>333</epage><pages>321-333</pages><issn>0950-9240</issn><eissn>1476-5527</eissn><abstract>Despite the established relationship of obesity to hypertension, the question as to whether there is a linear association between these two morbidities is unanswered. 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2
. The summary relative risk for a 10-cm increase in waist circumference was 1.25 (95% confidence interval: 1.19–1.32) and per 0.1-unit increase in waist-to-hip ratio was 1.27 (95% confidence interval: 1.18–1.37). This meta-analysis suggests that in normal range of obesity indexes, as lean as possible may be the best suggestion to prevent hypertension incidence.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29581553</pmid><doi>10.1038/s41371-018-0046-1</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-5091-6621</orcidid><orcidid>https://orcid.org/0000-0001-7076-2594</orcidid></addata></record> |
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| subjects | 631/443/592/75/243 692/700/459/1748 Adipose tissue Adipose tissues Body Mass Index Cardiovascular research Epidemiology Health Administration Health aspects Health risk assessment Hip Humans Hypertension Hypertension - epidemiology Hypertension - etiology Incidence Medicine Medicine & Public Health Meta-analysis Obesity Obesity - complications Obesity - diagnosis Prospective Studies Public Health Review Article Risk assessment Risk factors Waist Circumference Waist-Hip Ratio |
| title | Body mass index, abdominal fatness, and hypertension incidence: a dose-response meta-analysis of prospective studies |
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