Matteson Homologation-Based Total Synthesis of Lagunamide A

Matteson Homologation-Based Total Synthesis of Lagunamide A

Matteson homologation was found to be an excellent tool for the synthesis of the polyketide fragment of lagunamide A. Starting from a chiral boronic ester, a central building block containing all stereogenic centers of the polyketide chain was synthesized via six iterative Matteson homologation step...

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Veröffentlicht in:Organic letters 2018-04, Vol.20 (7), p.2033-2036
Hauptverfasser: Gorges, Jan, Kazmaier, Uli
Format: Artikel
Sprache:eng
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Zusammenfassung:Matteson homologation was found to be an excellent tool for the synthesis of the polyketide fragment of lagunamide A. Starting from a chiral boronic ester, a central building block containing all stereogenic centers of the polyketide chain was synthesized via six iterative Matteson homologation steps.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b00576