Deal Breaker: Semaphorin and Specificity in the Spinal Stretch Reflex Circuit

Stretch reflex circuits are a prime example of wiring specificity in the vertebrate spinal cord. Homonymous sensory afferents and motoneurons typically form monosynaptic connections, while neurons innervating antagonistic or unrelated muscles do not. Pecho-Vrieseling et al. now show that the semapho...

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Veröffentlicht in:Neuron (Cambridge, Mass.) Mass.), 2009-07, Vol.63 (1), p.8-11
Hauptverfasser: Maro, Geraldine S, Shen, Kang, Cheng, Hwai-Jong
Format: Artikel
Sprache:eng
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Zusammenfassung:Stretch reflex circuits are a prime example of wiring specificity in the vertebrate spinal cord. Homonymous sensory afferents and motoneurons typically form monosynaptic connections, while neurons innervating antagonistic or unrelated muscles do not. Pecho-Vrieseling et al. now show that the semaphorin Sema3E and its receptor Plexin-D1 prevent monosynaptic connectivity in the cutaneous maximus muscle stretch reflex circuit.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2009.07.002Preview