Deal Breaker: Semaphorin and Specificity in the Spinal Stretch Reflex Circuit
Stretch reflex circuits are a prime example of wiring specificity in the vertebrate spinal cord. Homonymous sensory afferents and motoneurons typically form monosynaptic connections, while neurons innervating antagonistic or unrelated muscles do not. Pecho-Vrieseling et al. now show that the semapho...
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Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2009-07, Vol.63 (1), p.8-11 |
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Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Stretch reflex circuits are a prime example of wiring specificity in the vertebrate spinal cord. Homonymous sensory afferents and motoneurons typically form monosynaptic connections, while neurons innervating antagonistic or unrelated muscles do not. Pecho-Vrieseling et al. now show that the semaphorin Sema3E and its receptor Plexin-D1 prevent monosynaptic connectivity in the cutaneous maximus muscle stretch reflex circuit. |
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ISSN: | 0896-6273 1097-4199 |
DOI: | 10.1016/j.neuron.2009.07.002Preview |