Access to Quaternary Stereogenic Centers via Rhodium(III)-Catalyzed Annulations between 2‑Phenylindoles and Ketenes

Rh­(III)-catalyzed C–H activation of arenes and mild oxidative [4 + 2] annulative coupling with ketenes have been realized. The uniquely high reactivity of the C(3) of 2-phenylindoles was successfully utilized to facilitate the reductive elimination process, leading to efficient synthesis of cyclic products with a quaternary carbon stereocenter.