Immunology of oligodendrocyte precursor cells in vivo and in vitro

Remyelination following myelin/oligodendrocyte injury in the central nervous system (CNS) is dependent on oligodendrocyte progenitor cells (OPCs) migrating into lesion sites, differentiating into myelinating oligodendrocytes (OLs), and ensheathing axons. Experimental models indicate that robust OPC-dependent remyelination can occur in the CNS; in contrast, histologic and imaging studies of lesions in the human disease multiple sclerosis (MS) indicate the variable extent of this response, which is particularly limited in more chronic MS lesions. Immune-mediated mechanisms can contribute either positively or negatively to the presence and functional responses of OPCs. This review addresses i) the molecular signature and functional properties of OPCs in the adult human brain; ii) the status (presence and function) of OPCs in MS lesions; iii) experimental models and in vitro data highlighting the contribution of adaptive and innate immune constituents to OPC injury and remyelination; and iv) effects of MS-directed immunotherapies on OPCs, either directly or indirectly via effects on specific immune constituents. [Display omitted] •A review of the molecular and functional properties of OPCs in the human adult brain.•Review of the evidence of the existence, identification and role of OPCs in multiple sclerosis lesions.•Detailing the effect of the adaptive and innate immune systems on OPC injury and OPC-mediated remyelination.•Understanding the direct or indirect effects of multiple sclerosis therapies on OPCs.