Cytokine Responses in Severe Traumatic Brain Injury: Where There Is Smoke, Is There Fire?

Cytokine Responses in Severe Traumatic Brain Injury: Where There Is Smoke, Is There Fire?

This scoping review will discuss the basic functions and prognostic significance of the commonly researched cytokines implicated in severe traumatic brain injury (sTBI), including tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, tissue inhibitor of matrix metalloproteinases-1 (TIMP-1)...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neurocritical care 2019-02, Vol.30 (1), p.22-32
Hauptverfasser: Casault, Colin, Al Sultan, Abdulaziz S., Banoei, Mohammad, Couillard, Philippe, Kramer, Andreas, Winston, Brent W.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biomarkers - metabolism
Brain Injuries, Traumatic - diagnosis
Brain Injuries, Traumatic - immunology
Brain Injuries, Traumatic - metabolism
Critical Care Medicine
Cytokines - metabolism
Humans
Intensive
Internal Medicine
Kinases
Medicine
Medicine & Public Health
Mortality
Neurology
Review Article
Traumatic brain injury
Tumor necrosis factor-TNF
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:This scoping review will discuss the basic functions and prognostic significance of the commonly researched cytokines implicated in severe traumatic brain injury (sTBI), including tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), transforming growth factor-β (TGF-β), substance P, and soluble CD40 ligand (sCD40L). A scoping review was undertaken with an electronic search for articles from the Ovid MEDLINE, PUBMED and EMBASE databases from 1995 to 2017. Inclusion criteria were original research articles, and reviews including both animal models and human clinical studies of acute (
ISSN:1541-6933
1556-0961
DOI:10.1007/s12028-018-0522-z