Clinical significance of FAP-α on microvessel and lymphatic vessel density in lung squamous cell carcinoma

AimsWe aimed to determine whether cancer-associated fibroblasts (CAFs) are associated with microvessel density (MVD) and lymphatic vessel density (LVD) in lung squamous cell carcinoma, as well as their clinical significance in predicting survival.Methods122 patients were enrolled in the study. Sampl...

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Veröffentlicht in:Journal of clinical pathology 2018-08, Vol.71 (8), p.721-728
Hauptverfasser: Chen, Ling, Chen, Meihui, Han, Zenglei, Jiang, Fengxing, Xu, Chunyuan, Qin, Yue, Ding, Ning, Liu, Yang, Zhang, Tenglong, An, Zhijie, Guo, Chengye
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Sprache:eng
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Zusammenfassung:AimsWe aimed to determine whether cancer-associated fibroblasts (CAFs) are associated with microvessel density (MVD) and lymphatic vessel density (LVD) in lung squamous cell carcinoma, as well as their clinical significance in predicting survival.Methods122 patients were enrolled in the study. Samples were obtained on resection at the Department of Thoracic Surgery of the Qingdao Municipal Hospital between January 2011 and December 2014. Immunohistochemistry was used to determine vessel and lymphatic vessel density, and CAF abundance (fibroblast activation protein α (FAP-α) positivity). Statistical analyses were performed on 85 patients to test for correlation of CAF density and other clinicopathological variables with 3-year overall survival (OS) and disease-free survival (DFS).ResultsHigh stromal CAF abundance significantly correlated with increased MVD and LVD in lung squamous cell carcinoma (p
ISSN:0021-9746
1472-4146
DOI:10.1136/jclinpath-2017-204872