Sequential high intensity focused ultrasound (HIFU) ablation in the treatment of benign multinodular goitre: an observational retrospective study
Objectives Assessing the efficacy and safety of sequential high-intensity focused ultrasound (HIFU) ablation in a multinodular goitre (MNG) by comparing them with single HIFU ablation. Methods One hundred and four (84.6%) patients underwent single ablation of a single nodule (group I), while 19 (15....
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| Veröffentlicht in: | European radiology 2018-08, Vol.28 (8), p.3237-3244 |
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| creator | Lang, Brian H. H. Woo, Yu-Cho Chiu, Keith Wan-Hang |
| description | Objectives
Assessing the efficacy and safety of sequential high-intensity focused ultrasound (HIFU) ablation in a multinodular goitre (MNG) by comparing them with single HIFU ablation.
Methods
One hundred and four (84.6%) patients underwent single ablation of a single nodule (group I), while 19 (15.4%) underwent sequential ablation of two relatively-dominant nodules in a MNG (group II). Extent of shrinkage per nodule [by volume reduction ratio (VRR)], pain scores (by 0-10 visual analogue scale) during and after ablation, and rate of vocal cord palsy (VCP), skin burn and nausea/vomiting were compared between the two groups.
Results
All 19 (100%) sequential ablations completed successfully. The 3- and 6-month VRR of each nodule were comparable between the two groups (
p
> 0.05) and in group II, the 3- and 6-month VRR between the first and second nodules were comparable (
p
= 0.710 and
p
= 0.548, respectively). Pain score was significantly higher in group II in the morning after ablation (2.29 vs 1.15,
p
= 0.047) and nausea/vomiting occurred significantly more frequently in group II (15.8% vs 0.0%,
p
= 0.012). However, VCP and skin burn were comparable (
p
> 0.05).
Conclusions
Sequential ablation had comparable efficacy and safety as single ablation. However, patients undergoing sequential ablation are at higher likelihood of pain in the following morning and nausea/vomiting after ablation.
Key Points
• Sequential HIFU ablation is well-tolerated in patients with two dominant thyroid nodules
• More pain is experienced in the morning following sequential HIFU ablation
• More nausea/vomiting is experienced following sequential HIFU ablation |
| doi_str_mv | 10.1007/s00330-018-5333-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2015841262</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2015841262</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-ad18bac47fa1f45df1747e600a89645c4a4c2ff4c3dc710aabd06dc15e02b5273</originalsourceid><addsrcrecordid>eNp1kc1u1DAURi0EokPhAdggS2zKInD9kzhhV1WUVqrEArqOHPtmxlViD7ZTaR6DN66HtCAhsfLC5_uurw8hbxl8ZADqUwIQAipgbVULISr-jGyYFLxi0MrnZAOdaCvVdfKEvErpDgA6JtVLcsK7um5U023Ir-_4c0GfnZ7ozm131PmMPrl8oGMwS0JLlylHncLiLT27ur68_UD1MOnsgi8wzTukOaLOc2mhYaQDerf1dC4x54NdJh3pNrjCfKba0zAkjPe_42VkxBxD2qPJ7h5pyos9vCYvRj0lfPN4npLbyy8_Lq6qm29fry_ObyojFM-VtqwdtJFq1GyUtR2ZkgobAN12jayN1NLwcZRGWKMYaD1YaKxhNQIfaq7EKTlbe_cxlC9IuZ9dMjhN2mNYUs-B1a1kvOEFff8PeheWWN6_UrJWTdsViq2UKSuliGO_j27W8dAz6I---tVXX3z1R1_9sfndY_MyzGj_JJ4EFYCvQCpXfovx7-j_tz4AeiijYw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2015457689</pqid></control><display><type>article</type><title>Sequential high intensity focused ultrasound (HIFU) ablation in the treatment of benign multinodular goitre: an observational retrospective study</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Lang, Brian H. H. ; Woo, Yu-Cho ; Chiu, Keith Wan-Hang</creator><creatorcontrib>Lang, Brian H. H. ; Woo, Yu-Cho ; Chiu, Keith Wan-Hang</creatorcontrib><description>Objectives
Assessing the efficacy and safety of sequential high-intensity focused ultrasound (HIFU) ablation in a multinodular goitre (MNG) by comparing them with single HIFU ablation.
Methods
One hundred and four (84.6%) patients underwent single ablation of a single nodule (group I), while 19 (15.4%) underwent sequential ablation of two relatively-dominant nodules in a MNG (group II). Extent of shrinkage per nodule [by volume reduction ratio (VRR)], pain scores (by 0-10 visual analogue scale) during and after ablation, and rate of vocal cord palsy (VCP), skin burn and nausea/vomiting were compared between the two groups.
Results
All 19 (100%) sequential ablations completed successfully. The 3- and 6-month VRR of each nodule were comparable between the two groups (
p
> 0.05) and in group II, the 3- and 6-month VRR between the first and second nodules were comparable (
p
= 0.710 and
p
= 0.548, respectively). Pain score was significantly higher in group II in the morning after ablation (2.29 vs 1.15,
p
= 0.047) and nausea/vomiting occurred significantly more frequently in group II (15.8% vs 0.0%,
p
= 0.012). However, VCP and skin burn were comparable (
p
> 0.05).
Conclusions
Sequential ablation had comparable efficacy and safety as single ablation. However, patients undergoing sequential ablation are at higher likelihood of pain in the following morning and nausea/vomiting after ablation.
Key Points
• Sequential HIFU ablation is well-tolerated in patients with two dominant thyroid nodules
• More pain is experienced in the morning following sequential HIFU ablation
• More nausea/vomiting is experienced following sequential HIFU ablation</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-018-5333-2</identifier><identifier>PMID: 29556769</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Ablation ; Adult ; Aged ; Burns - etiology ; Diagnostic Radiology ; Female ; Goiter - surgery ; High-Intensity Focused Ultrasound Ablation - adverse effects ; High-Intensity Focused Ultrasound Ablation - methods ; Humans ; Imaging ; Internal Medicine ; Interventional ; Interventional Radiology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Morning ; Nausea ; Nausea - etiology ; Neuroradiology ; Nodules ; Pain ; Pain - etiology ; Pain Measurement ; Paralysis ; Patients ; Radiology ; Retrospective Studies ; Safety ; Shrinkage ; Skin ; Thyroid ; Thyroid Nodule - surgery ; Treatment Outcome ; Ultrasonic imaging ; Ultrasound ; Vocal Cord Paralysis - etiology ; Vomiting</subject><ispartof>European radiology, 2018-08, Vol.28 (8), p.3237-3244</ispartof><rights>European Society of Radiology 2018</rights><rights>European Radiology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-ad18bac47fa1f45df1747e600a89645c4a4c2ff4c3dc710aabd06dc15e02b5273</citedby><cites>FETCH-LOGICAL-c372t-ad18bac47fa1f45df1747e600a89645c4a4c2ff4c3dc710aabd06dc15e02b5273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-018-5333-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-018-5333-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29556769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lang, Brian H. H.</creatorcontrib><creatorcontrib>Woo, Yu-Cho</creatorcontrib><creatorcontrib>Chiu, Keith Wan-Hang</creatorcontrib><title>Sequential high intensity focused ultrasound (HIFU) ablation in the treatment of benign multinodular goitre: an observational retrospective study</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives
Assessing the efficacy and safety of sequential high-intensity focused ultrasound (HIFU) ablation in a multinodular goitre (MNG) by comparing them with single HIFU ablation.
Methods
One hundred and four (84.6%) patients underwent single ablation of a single nodule (group I), while 19 (15.4%) underwent sequential ablation of two relatively-dominant nodules in a MNG (group II). Extent of shrinkage per nodule [by volume reduction ratio (VRR)], pain scores (by 0-10 visual analogue scale) during and after ablation, and rate of vocal cord palsy (VCP), skin burn and nausea/vomiting were compared between the two groups.
Results
All 19 (100%) sequential ablations completed successfully. The 3- and 6-month VRR of each nodule were comparable between the two groups (
p
> 0.05) and in group II, the 3- and 6-month VRR between the first and second nodules were comparable (
p
= 0.710 and
p
= 0.548, respectively). Pain score was significantly higher in group II in the morning after ablation (2.29 vs 1.15,
p
= 0.047) and nausea/vomiting occurred significantly more frequently in group II (15.8% vs 0.0%,
p
= 0.012). However, VCP and skin burn were comparable (
p
> 0.05).
Conclusions
Sequential ablation had comparable efficacy and safety as single ablation. However, patients undergoing sequential ablation are at higher likelihood of pain in the following morning and nausea/vomiting after ablation.
Key Points
• Sequential HIFU ablation is well-tolerated in patients with two dominant thyroid nodules
• More pain is experienced in the morning following sequential HIFU ablation
• More nausea/vomiting is experienced following sequential HIFU ablation</description><subject>Ablation</subject><subject>Adult</subject><subject>Aged</subject><subject>Burns - etiology</subject><subject>Diagnostic Radiology</subject><subject>Female</subject><subject>Goiter - surgery</subject><subject>High-Intensity Focused Ultrasound Ablation - adverse effects</subject><subject>High-Intensity Focused Ultrasound Ablation - methods</subject><subject>Humans</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional</subject><subject>Interventional Radiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Morning</subject><subject>Nausea</subject><subject>Nausea - etiology</subject><subject>Neuroradiology</subject><subject>Nodules</subject><subject>Pain</subject><subject>Pain - etiology</subject><subject>Pain Measurement</subject><subject>Paralysis</subject><subject>Patients</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Safety</subject><subject>Shrinkage</subject><subject>Skin</subject><subject>Thyroid</subject><subject>Thyroid Nodule - surgery</subject><subject>Treatment Outcome</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><subject>Vocal Cord Paralysis - etiology</subject><subject>Vomiting</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kc1u1DAURi0EokPhAdggS2zKInD9kzhhV1WUVqrEArqOHPtmxlViD7ZTaR6DN66HtCAhsfLC5_uurw8hbxl8ZADqUwIQAipgbVULISr-jGyYFLxi0MrnZAOdaCvVdfKEvErpDgA6JtVLcsK7um5U023Ir-_4c0GfnZ7ozm131PmMPrl8oGMwS0JLlylHncLiLT27ur68_UD1MOnsgi8wzTukOaLOc2mhYaQDerf1dC4x54NdJh3pNrjCfKba0zAkjPe_42VkxBxD2qPJ7h5pyos9vCYvRj0lfPN4npLbyy8_Lq6qm29fry_ObyojFM-VtqwdtJFq1GyUtR2ZkgobAN12jayN1NLwcZRGWKMYaD1YaKxhNQIfaq7EKTlbe_cxlC9IuZ9dMjhN2mNYUs-B1a1kvOEFff8PeheWWN6_UrJWTdsViq2UKSuliGO_j27W8dAz6I---tVXX3z1R1_9sfndY_MyzGj_JJ4EFYCvQCpXfovx7-j_tz4AeiijYw</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Lang, Brian H. H.</creator><creator>Woo, Yu-Cho</creator><creator>Chiu, Keith Wan-Hang</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20180801</creationdate><title>Sequential high intensity focused ultrasound (HIFU) ablation in the treatment of benign multinodular goitre: an observational retrospective study</title><author>Lang, Brian H. H. ; Woo, Yu-Cho ; Chiu, Keith Wan-Hang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-ad18bac47fa1f45df1747e600a89645c4a4c2ff4c3dc710aabd06dc15e02b5273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Ablation</topic><topic>Adult</topic><topic>Aged</topic><topic>Burns - etiology</topic><topic>Diagnostic Radiology</topic><topic>Female</topic><topic>Goiter - surgery</topic><topic>High-Intensity Focused Ultrasound Ablation - adverse effects</topic><topic>High-Intensity Focused Ultrasound Ablation - methods</topic><topic>Humans</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional</topic><topic>Interventional Radiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Morning</topic><topic>Nausea</topic><topic>Nausea - etiology</topic><topic>Neuroradiology</topic><topic>Nodules</topic><topic>Pain</topic><topic>Pain - etiology</topic><topic>Pain Measurement</topic><topic>Paralysis</topic><topic>Patients</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Safety</topic><topic>Shrinkage</topic><topic>Skin</topic><topic>Thyroid</topic><topic>Thyroid Nodule - surgery</topic><topic>Treatment Outcome</topic><topic>Ultrasonic imaging</topic><topic>Ultrasound</topic><topic>Vocal Cord Paralysis - etiology</topic><topic>Vomiting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lang, Brian H. H.</creatorcontrib><creatorcontrib>Woo, Yu-Cho</creatorcontrib><creatorcontrib>Chiu, Keith Wan-Hang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lang, Brian H. H.</au><au>Woo, Yu-Cho</au><au>Chiu, Keith Wan-Hang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sequential high intensity focused ultrasound (HIFU) ablation in the treatment of benign multinodular goitre: an observational retrospective study</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>28</volume><issue>8</issue><spage>3237</spage><epage>3244</epage><pages>3237-3244</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objectives
Assessing the efficacy and safety of sequential high-intensity focused ultrasound (HIFU) ablation in a multinodular goitre (MNG) by comparing them with single HIFU ablation.
Methods
One hundred and four (84.6%) patients underwent single ablation of a single nodule (group I), while 19 (15.4%) underwent sequential ablation of two relatively-dominant nodules in a MNG (group II). Extent of shrinkage per nodule [by volume reduction ratio (VRR)], pain scores (by 0-10 visual analogue scale) during and after ablation, and rate of vocal cord palsy (VCP), skin burn and nausea/vomiting were compared between the two groups.
Results
All 19 (100%) sequential ablations completed successfully. The 3- and 6-month VRR of each nodule were comparable between the two groups (
p
> 0.05) and in group II, the 3- and 6-month VRR between the first and second nodules were comparable (
p
= 0.710 and
p
= 0.548, respectively). Pain score was significantly higher in group II in the morning after ablation (2.29 vs 1.15,
p
= 0.047) and nausea/vomiting occurred significantly more frequently in group II (15.8% vs 0.0%,
p
= 0.012). However, VCP and skin burn were comparable (
p
> 0.05).
Conclusions
Sequential ablation had comparable efficacy and safety as single ablation. However, patients undergoing sequential ablation are at higher likelihood of pain in the following morning and nausea/vomiting after ablation.
Key Points
• Sequential HIFU ablation is well-tolerated in patients with two dominant thyroid nodules
• More pain is experienced in the morning following sequential HIFU ablation
• More nausea/vomiting is experienced following sequential HIFU ablation</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29556769</pmid><doi>10.1007/s00330-018-5333-2</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2018-08, Vol.28 (8), p.3237-3244 |
| issn | 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2015841262 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Ablation Adult Aged Burns - etiology Diagnostic Radiology Female Goiter - surgery High-Intensity Focused Ultrasound Ablation - adverse effects High-Intensity Focused Ultrasound Ablation - methods Humans Imaging Internal Medicine Interventional Interventional Radiology Male Medicine Medicine & Public Health Middle Aged Morning Nausea Nausea - etiology Neuroradiology Nodules Pain Pain - etiology Pain Measurement Paralysis Patients Radiology Retrospective Studies Safety Shrinkage Skin Thyroid Thyroid Nodule - surgery Treatment Outcome Ultrasonic imaging Ultrasound Vocal Cord Paralysis - etiology Vomiting |
| title | Sequential high intensity focused ultrasound (HIFU) ablation in the treatment of benign multinodular goitre: an observational retrospective study |
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