Cell-loaded carboxymethylcellulose microspheres sustain viability and proliferation of ATDC5 cells

Cell-loaded carboxymethylcellulose (CMC) microspheres were generated via a flow focusing microfluidic device, with a final aim to obtain viable ATDC5 aggregates with sustained proliferation capacity. We synthesized various CMC with phenolic groups (CMC-Ph) and demonstrated that high CMC-Ph molecular...

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Veröffentlicht in:	Artificial cells, nanomedicine, and biotechnology nanomedicine, and biotechnology, 2018-01, Vol.46 (sup2), p.140-151
Hauptverfasser:	Ke, Yu, Liu, Caikun, Wang, Yanting, Xiao, Meng, Fan, Jiachen, Fu, Pengcheng, Wang, Shuhao, Wu, Gang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates ATDC5 Biomaterials Biomedical materials Carboxymethylcellulose Cell culture Cell density Cell proliferation cell-loaded microspheres Cytology fast gelation Gelation Gels Horseradish peroxidase Hydrogen peroxide microfluidic Microfluidics Microspheres Molecular weight Morphology Peroxidase Phenolic compounds Tissue engineering Viability
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Beschreibung
Zusammenfassung:	Cell-loaded carboxymethylcellulose (CMC) microspheres were generated via a flow focusing microfluidic device, with a final aim to obtain viable ATDC5 aggregates with sustained proliferation capacity. We synthesized various CMC with phenolic groups (CMC-Ph) and demonstrated that high CMC-Ph molecular weight, high CMC-Ph concentration (>0.8 g/ml) or long culturing period had obvious inhibition effect on ATDC5 proliferation, but low horseradish peroxidase concentration (HRP,
ISSN:	2169-1401 2169-141X
DOI:	10.1080/21691401.2018.1452751