Intramolecular hydrogen-bond activation for the addition of nucleophilic imines: 2-hydroxybenzophenone as a chemical auxiliary

Intramolecular hydrogen-bond activation for the addition of nucleophilic imines: 2-hydroxybenzophenone as a chemical auxiliary

The addition of nucleophilic imines, using 2-hydroxybenzophenone as a chemical auxiliary, is presented. An intramolecular six-membered ring via hydrogen bonding that enhances the reactivity and selectivity is the key of this strategy, which is supported by DFT calculations and experimental trials.

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (27), p.3399-3402
Hauptverfasser: Choubane, Houcine, Garrido-Castro, Alberto F, Alvarado, Cuauhtemoc, Martín-Somer, Ana, Guerrero-Corella, Andrea, Daaou, Mortada, Díaz-Tendero, Sergio, Carmen Maestro, M, Fraile, Alberto, Alemán, José
Format: Artikel
Sprache:eng
Schlagworte:
Chemical bonds
Hydrogen bonding
Imines
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The addition of nucleophilic imines, using 2-hydroxybenzophenone as a chemical auxiliary, is presented. An intramolecular six-membered ring via hydrogen bonding that enhances the reactivity and selectivity is the key of this strategy, which is supported by DFT calculations and experimental trials.
ISSN:1359-7345
1364-548X
DOI:10.1039/C8CC01479E