NF-κB pathways in the development and progression of colorectal cancer

Nuclear factor-κB (NF-κB) has been widely implicated in the development and progression of cancer. In colorectal cancer (CRC), NF-κB has a key role in cancer-related processes such as cell proliferation, apoptosis, angiogenesis, and metastasis. The role of NF-κB in CRC is complex, owed to the cross...

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Veröffentlicht in:Translational research : the journal of laboratory and clinical medicine 2018-07, Vol.197, p.43-56
Hauptverfasser: Patel, Meera, Horgan, Paul G., McMillan, Donald C., Edwards, Joanne
Format: Artikel
Sprache:eng
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Zusammenfassung:Nuclear factor-κB (NF-κB) has been widely implicated in the development and progression of cancer. In colorectal cancer (CRC), NF-κB has a key role in cancer-related processes such as cell proliferation, apoptosis, angiogenesis, and metastasis. The role of NF-κB in CRC is complex, owed to the cross talk with other signaling pathways. Although there is sufficient evidence gained from cell lines and animal models that NF-κB is involved in cancer-related processes, because of a lack of studies in human tissue, the clinical evidence of its importance is limited in patients with CRC. This review summarizes evidence relating to how NF-κB is involved in the development and progression of CRC and comments on future work to be carried out.
ISSN:1931-5244
1878-1810
DOI:10.1016/j.trsl.2018.02.002