The potential of aptamers for cancer research

The potential of aptamers for cancer research

Aptamers are promising alternatives to antibodies and can be used as high affinity agents for the cancer detection and the targeted drug transportation. In this manuscript, we highlight the advantages of aptamers, such as high affinities, specificity and excellent chemical stabilities, which are lik...

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Veröffentlicht in:Analytical biochemistry 2018-05, Vol.549, p.91-95
Hauptverfasser: Zhou, Zhizhi, Liu, Mingying, Jiang, Jiahuan
Format: Artikel
Sprache:eng
Schlagworte:
Aptamer
Aptasensor
Biomarker
Nucleic acids
SELEX
Tumor cell
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Zusammenfassung:Aptamers are promising alternatives to antibodies and can be used as high affinity agents for the cancer detection and the targeted drug transportation. In this manuscript, we highlight the advantages of aptamers, such as high affinities, specificity and excellent chemical stabilities, which are likely to benefit for the diagnosis of cancer in its early stages and then achieve molecular-level treatment. Also, we discuss the challenges and problems in the current application of aptamers.
ISSN:0003-2697
1096-0309
DOI:10.1016/j.ab.2018.03.008