Antiproliferative, Antioxidant, and Antimutagenic Activities of Flavonoid-Enriched Extracts from (Tunisian) Rhamnus alaternus L.: Combination with the Phytochemical Composition

A pronounced antiproliferative effect on human leukemia K562 cells was shown with flavonoid-enriched extracts from Rhamnus alaternus roots and leaves, with, respectively, IC50 values of 165 and 210.73 μg mL. High DPPH radical-scavenging activity (7.21 and 18.84 μg mL, respectively) and antioxidative...

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Veröffentlicht in:	Drug and chemical toxicology (New York, N.Y. 1978) N.Y. 1978), 2008, Vol.31 (1), p.61-80
Hauptverfasser:	Ben Ammar, Rebai, Kilani, Soumaya, Bouhlel, Ines, Ezzi, Lobna, Skandrani, Ines, Boubaker, Jihed, Ben Sghaier, Mohamed, Naffeti, Aicha, Mahmoud, Amor, Chekir-Ghedira, Leila, Ghedira, Kamel
Format:	Artikel
Sprache:	eng
Schlagworte:	Ames test Animals Antimutagenic activity Antimutagenic Agents - chemistry Antimutagenic Agents - pharmacology Antimutagenic Agents - toxicity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - toxicity antioxidant effect Antioxidants - chemistry Antioxidants - pharmacology Antioxidants - toxicity Antiproliferative effect Biological and medical sciences Cell Proliferation - drug effects DNA, Bacterial - drug effects Dose-Response Relationship, Drug DPPH Flavonoids - analysis Free Radical Scavengers - pharmacology Humans Inhibitory Concentration 50 K562 Cells Medical sciences Mice MII Mutation - drug effects Photochemical composition Plant Components, Aerial Plant Extracts - pharmacology Plant poisons toxicology Plant Roots Rhamnus - chemistry Rhamnus alatemus (Rhamnacae) Rhamnus alaternus Salmonella typhimurium Salmonella typhimurium - drug effects Salmonella typhimurium - genetics Sodium Azide - pharmacology Superoxide anions Superoxides - chemistry Toxicology Xanthine oxidase Xanthine Oxidase - antagonists & inhibitors Xanthine Oxidase - metabolism
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Zusammenfassung:	A pronounced antiproliferative effect on human leukemia K562 cells was shown with flavonoid-enriched extracts from Rhamnus alaternus roots and leaves, with, respectively, IC50 values of 165 and 210.73 μg mL. High DPPH radical-scavenging activity (7.21 and 18.84 μg mL, respectively) and antioxidative effects using the xanthine oxidase assay (IC50 values of 83.33 and 103.96 μg mL, respectively) were detected in the presence of the two tested extracts. Although no mutagenic effect was observed when using the Salmonella typhimurium assay system with TA1535 and TA100 strains, the two tested extracts exhibited a high-level protection toward the direct mutagen, sodium azide-induced response.
ISSN:	0148-0545 1525-6014
DOI:	10.1080/01480540701688725