Impact of Body Weight Loss From Maximum Weight on Fragility Bone Fractures in Japanese Patients With Type 2 Diabetes: The Fukuoka Diabetes Registry
There is growing evidence that weight loss is associated with increased fracture risk in the general population. As patients with diabetes often lose weight intentionally or unintentionally, we aimed to investigate prospectively the relationship between weight loss from maximum body weight and fract...
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| Veröffentlicht in: | Diabetes care 2018-05, Vol.41 (5), p.1061-1067 |
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| creator | Komorita, Yuji Iwase, Masanori Fujii, Hiroki Ohkuma, Toshiaki Ide, Hitoshi Jodai-Kitamura, Tamaki Sumi, Akiko Yoshinari, Masahito Nakamura, Udai Kang, Dongchon Kitazono, Takanari |
| description | There is growing evidence that weight loss is associated with increased fracture risk in the general population. As patients with diabetes often lose weight intentionally or unintentionally, we aimed to investigate prospectively the relationship between weight loss from maximum body weight and fracture risk.
A total of 4,706 Japanese participants with type 2 diabetes (mean age 66 years), including 2,755 men and 1,951 postmenopausal women, were followed for a median of 5.3 years and were divided according to weight loss from maximum weight: |
| doi_str_mv | 10.2337/dc17-2004 |
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A total of 4,706 Japanese participants with type 2 diabetes (mean age 66 years), including 2,755 men and 1,951 postmenopausal women, were followed for a median of 5.3 years and were divided according to weight loss from maximum weight: <10%, 10% to <20%, 20% to <30%, and ≥30%. The primary outcomes were fragility fractures defined as fractures at sites of hip and spine.
During the follow-up period, fragility fractures occurred in 198 participants. The age- and sex-adjusted incidence rates per 1,000 person-years in all participants were 6.4 (<10% weight loss from maximum body weight), 7.8 (10% to <20%), 11.7 (20% to <30%), and 19.2 (≥30%) (
for trend <0.001). Multivariate-adjusted hazard ratios for fragility fractures compared with reference (<10% weight loss) were 1.48 (95% CI 0.79-2.77) in the 10% to <20% group, 2.23 (1.08-4.64) in 20% to <30%, and 5.20 (2.15-12.57) in ≥30% in men, and 1.19 (0.78-1.82) in 10% to <20%, 1.62 (0.96-2.73) in 20% to <30%, and 1.97 (0.84-4.62) in ≥30% in postmenopausal women.
The current study demonstrates that ≥20% body weight loss from maximum weight is a significant risk factor for fragility fractures in patients with type 2 diabetes, especially in men.]]></description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc17-2004</identifier><identifier>PMID: 29540432</identifier><language>eng</language><publisher>United States: American Diabetes Association</publisher><subject>Body weight ; Body weight loss ; Bones ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Fractures ; Fragility ; Hip ; Impact analysis ; Men ; Patients ; Post-menopause ; Research design ; Risk analysis ; Risk factors ; Spine ; Weight control ; Weight loss</subject><ispartof>Diabetes care, 2018-05, Vol.41 (5), p.1061-1067</ispartof><rights>2018 by the American Diabetes Association.</rights><rights>Copyright American Diabetes Association May 1, 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-c09f4e56c0cb3b1f8f8d7151b551d25e8e03d18c1e2e65cb3cd812e2c039804e3</citedby><cites>FETCH-LOGICAL-c348t-c09f4e56c0cb3b1f8f8d7151b551d25e8e03d18c1e2e65cb3cd812e2c039804e3</cites><orcidid>0000-0001-9727-7644</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29540432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Komorita, Yuji</creatorcontrib><creatorcontrib>Iwase, Masanori</creatorcontrib><creatorcontrib>Fujii, Hiroki</creatorcontrib><creatorcontrib>Ohkuma, Toshiaki</creatorcontrib><creatorcontrib>Ide, Hitoshi</creatorcontrib><creatorcontrib>Jodai-Kitamura, Tamaki</creatorcontrib><creatorcontrib>Sumi, Akiko</creatorcontrib><creatorcontrib>Yoshinari, Masahito</creatorcontrib><creatorcontrib>Nakamura, Udai</creatorcontrib><creatorcontrib>Kang, Dongchon</creatorcontrib><creatorcontrib>Kitazono, Takanari</creatorcontrib><title>Impact of Body Weight Loss From Maximum Weight on Fragility Bone Fractures in Japanese Patients With Type 2 Diabetes: The Fukuoka Diabetes Registry</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description><![CDATA[There is growing evidence that weight loss is associated with increased fracture risk in the general population. As patients with diabetes often lose weight intentionally or unintentionally, we aimed to investigate prospectively the relationship between weight loss from maximum body weight and fracture risk.
A total of 4,706 Japanese participants with type 2 diabetes (mean age 66 years), including 2,755 men and 1,951 postmenopausal women, were followed for a median of 5.3 years and were divided according to weight loss from maximum weight: <10%, 10% to <20%, 20% to <30%, and ≥30%. The primary outcomes were fragility fractures defined as fractures at sites of hip and spine.
During the follow-up period, fragility fractures occurred in 198 participants. The age- and sex-adjusted incidence rates per 1,000 person-years in all participants were 6.4 (<10% weight loss from maximum body weight), 7.8 (10% to <20%), 11.7 (20% to <30%), and 19.2 (≥30%) (
for trend <0.001). Multivariate-adjusted hazard ratios for fragility fractures compared with reference (<10% weight loss) were 1.48 (95% CI 0.79-2.77) in the 10% to <20% group, 2.23 (1.08-4.64) in 20% to <30%, and 5.20 (2.15-12.57) in ≥30% in men, and 1.19 (0.78-1.82) in 10% to <20%, 1.62 (0.96-2.73) in 20% to <30%, and 1.97 (0.84-4.62) in ≥30% in postmenopausal women.
The current study demonstrates that ≥20% body weight loss from maximum weight is a significant risk factor for fragility fractures in patients with type 2 diabetes, especially in men.]]></description><subject>Body weight</subject><subject>Body weight loss</subject><subject>Bones</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Fractures</subject><subject>Fragility</subject><subject>Hip</subject><subject>Impact analysis</subject><subject>Men</subject><subject>Patients</subject><subject>Post-menopause</subject><subject>Research design</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Spine</subject><subject>Weight control</subject><subject>Weight loss</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkU1P3DAQhq2qqCy0B_4AstRLOQT8uWv3RvkooEWtqq04Ro4z2TVs4mA7Evkd_OE64uPQ02hmnhnNvC9CB5QcM84XJ7Wli4IRIj6gGdVcFlIK9RHNCBW6kFqzXbQX4z3JhFDqE9plWgoiOJuh5-u2NzZh3-Afvh7xHbj1JuGljxFfBt_iW_Pk2qF9a_gul83abV0a80QHU2rTECBi1-Eb05sOIuDfJjnoUsR3Lm3wauwBM3zuTAUJ4ne82uTB4WHwD-a9iv_A2sUUxs9opzHbCF9e4z76e3mxOrsqlr9-Xp-dLgvLhUqFJboRIOeW2IpXtFGNqhdU0kpKWjMJCgivqbIUGMxlZmytKANmCdeKCOD76NvL3j74xwFiKlsXLWy3-QU_xJJl_aiQlOmMfv0PvfdD6PJ1mdJESrKYT9TRC2VD1i9AU_bBtSaMJSXl5FQ5OVVOTmX28HXjULVQv5Nv1vB_-YWNpA</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Komorita, Yuji</creator><creator>Iwase, Masanori</creator><creator>Fujii, Hiroki</creator><creator>Ohkuma, Toshiaki</creator><creator>Ide, Hitoshi</creator><creator>Jodai-Kitamura, Tamaki</creator><creator>Sumi, Akiko</creator><creator>Yoshinari, Masahito</creator><creator>Nakamura, Udai</creator><creator>Kang, Dongchon</creator><creator>Kitazono, Takanari</creator><general>American Diabetes Association</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-9727-7644</orcidid></search><sort><creationdate>201805</creationdate><title>Impact of Body Weight Loss From Maximum Weight on Fragility Bone Fractures in Japanese Patients With Type 2 Diabetes: The Fukuoka Diabetes Registry</title><author>Komorita, Yuji ; Iwase, Masanori ; Fujii, Hiroki ; Ohkuma, Toshiaki ; Ide, Hitoshi ; Jodai-Kitamura, Tamaki ; Sumi, Akiko ; Yoshinari, Masahito ; Nakamura, Udai ; Kang, Dongchon ; Kitazono, Takanari</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-c09f4e56c0cb3b1f8f8d7151b551d25e8e03d18c1e2e65cb3cd812e2c039804e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Body weight</topic><topic>Body weight loss</topic><topic>Bones</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Fractures</topic><topic>Fragility</topic><topic>Hip</topic><topic>Impact analysis</topic><topic>Men</topic><topic>Patients</topic><topic>Post-menopause</topic><topic>Research design</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Spine</topic><topic>Weight control</topic><topic>Weight loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Komorita, Yuji</creatorcontrib><creatorcontrib>Iwase, Masanori</creatorcontrib><creatorcontrib>Fujii, Hiroki</creatorcontrib><creatorcontrib>Ohkuma, Toshiaki</creatorcontrib><creatorcontrib>Ide, Hitoshi</creatorcontrib><creatorcontrib>Jodai-Kitamura, Tamaki</creatorcontrib><creatorcontrib>Sumi, Akiko</creatorcontrib><creatorcontrib>Yoshinari, Masahito</creatorcontrib><creatorcontrib>Nakamura, Udai</creatorcontrib><creatorcontrib>Kang, Dongchon</creatorcontrib><creatorcontrib>Kitazono, Takanari</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Komorita, Yuji</au><au>Iwase, Masanori</au><au>Fujii, Hiroki</au><au>Ohkuma, Toshiaki</au><au>Ide, Hitoshi</au><au>Jodai-Kitamura, Tamaki</au><au>Sumi, Akiko</au><au>Yoshinari, Masahito</au><au>Nakamura, Udai</au><au>Kang, Dongchon</au><au>Kitazono, Takanari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Body Weight Loss From Maximum Weight on Fragility Bone Fractures in Japanese Patients With Type 2 Diabetes: The Fukuoka Diabetes Registry</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2018-05</date><risdate>2018</risdate><volume>41</volume><issue>5</issue><spage>1061</spage><epage>1067</epage><pages>1061-1067</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><abstract><![CDATA[There is growing evidence that weight loss is associated with increased fracture risk in the general population. As patients with diabetes often lose weight intentionally or unintentionally, we aimed to investigate prospectively the relationship between weight loss from maximum body weight and fracture risk.
A total of 4,706 Japanese participants with type 2 diabetes (mean age 66 years), including 2,755 men and 1,951 postmenopausal women, were followed for a median of 5.3 years and were divided according to weight loss from maximum weight: <10%, 10% to <20%, 20% to <30%, and ≥30%. The primary outcomes were fragility fractures defined as fractures at sites of hip and spine.
During the follow-up period, fragility fractures occurred in 198 participants. The age- and sex-adjusted incidence rates per 1,000 person-years in all participants were 6.4 (<10% weight loss from maximum body weight), 7.8 (10% to <20%), 11.7 (20% to <30%), and 19.2 (≥30%) (
for trend <0.001). Multivariate-adjusted hazard ratios for fragility fractures compared with reference (<10% weight loss) were 1.48 (95% CI 0.79-2.77) in the 10% to <20% group, 2.23 (1.08-4.64) in 20% to <30%, and 5.20 (2.15-12.57) in ≥30% in men, and 1.19 (0.78-1.82) in 10% to <20%, 1.62 (0.96-2.73) in 20% to <30%, and 1.97 (0.84-4.62) in ≥30% in postmenopausal women.
The current study demonstrates that ≥20% body weight loss from maximum weight is a significant risk factor for fragility fractures in patients with type 2 diabetes, especially in men.]]></abstract><cop>United States</cop><pub>American Diabetes Association</pub><pmid>29540432</pmid><doi>10.2337/dc17-2004</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-9727-7644</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetes care, 2018-05, Vol.41 (5), p.1061-1067 |
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| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Body weight Body weight loss Bones Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Fractures Fragility Hip Impact analysis Men Patients Post-menopause Research design Risk analysis Risk factors Spine Weight control Weight loss |
| title | Impact of Body Weight Loss From Maximum Weight on Fragility Bone Fractures in Japanese Patients With Type 2 Diabetes: The Fukuoka Diabetes Registry |
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