Lyotropic Liquid Crystalline Nanoparticles of Amphotericin B: Implication of Phytantriol and Glyceryl Monooleate on Bioavailability Enhancement

Lyotropic Liquid Crystalline Nanoparticles of Amphotericin B: Implication of Phytantriol and Glyceryl Monooleate on Bioavailability Enhancement

Implication of different dietary specific lipids such as phytantriol (PT) and glyceryl monooleate (GMO) on enhancing the oral bioavailability of amphotericin B (AmB) was examined. Liquid crystalline nanoparticles (LCNPs) were prepared using hydrotrope method, followed by in vitro characterization, C...

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Veröffentlicht in:AAPS PharmSciTech 2018-05, Vol.19 (4), p.1699-1711
Hauptverfasser: Jain, Sanyog, Yadav, Pooja, Swami, Rajan, Swarnakar, Nitin Kumar, Kushwah, Varun, Katiyar, Sameer S.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Pharmacology/Toxicology
Pharmacy
Research Article
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Zusammenfassung:Implication of different dietary specific lipids such as phytantriol (PT) and glyceryl monooleate (GMO) on enhancing the oral bioavailability of amphotericin B (AmB) was examined. Liquid crystalline nanoparticles (LCNPs) were prepared using hydrotrope method, followed by in vitro characterization, Caco-2 cell monolayer uptake , and in vivo pharmacokinetic and toxicity evaluation. Optimized AmB-LCNPs displayed small particle size (
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-018-0986-3