Effect of high amylose resistant starch (HAM‐RS2) supplementation on biomarkers of inflammation and oxidative stress in hemodialysis patients: a randomized clinical trial

Introduction: Systemic inflammation and oxidative stress play a central role in the pathogenesis of cardiovascular disease and numerous other complications of CKD. Recent studies demonstrated that consumption of a diet enriched with amylose (HAM‐RS2), attenuates oxidative stress and inflammation, an...

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Veröffentlicht in:Hemodialysis international 2018-10, Vol.22 (4), p.492-500
Hauptverfasser: Tayebi Khosroshahi, Hamid, Vaziri, Nosratola D., Abedi, Behzad, Asl, Bahlol Habibi, Ghojazadeh, Morteza, Jing, Wanghui, Vatankhah, Amir Mansur
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container_issue 4
container_start_page 492
container_title Hemodialysis international
container_volume 22
creator Tayebi Khosroshahi, Hamid
Vaziri, Nosratola D.
Abedi, Behzad
Asl, Bahlol Habibi
Ghojazadeh, Morteza
Jing, Wanghui
Vatankhah, Amir Mansur
description Introduction: Systemic inflammation and oxidative stress play a central role in the pathogenesis of cardiovascular disease and numerous other complications of CKD. Recent studies demonstrated that consumption of a diet enriched with amylose (HAM‐RS2), attenuates oxidative stress and inflammation, and improves intestinal microbiome in CKD rats. The present study was designed to explore the effect of dietary amylose supplementation in hemodialysis patients. Methods: Forty‐six stable hemodialysis patients were randomized to receive biscuits containing 20 g/day during the first four weeks and 25 g/day in the next four weeks of either HAM‐RS2 or wheat‐flour. Fasting predialysis blood samples obtained before, during and at the end of trial were processed for biomarkers of oxidative stress and inflammation. Findings: There was no significant difference in baseline clinical or biochemical parameters between the two groups. Serum levels of TNF‐α, IL‐6, and malondialdehyde declined significantly (P 
doi_str_mv 10.1111/hdi.12653
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Recent studies demonstrated that consumption of a diet enriched with amylose (HAM‐RS2), attenuates oxidative stress and inflammation, and improves intestinal microbiome in CKD rats. The present study was designed to explore the effect of dietary amylose supplementation in hemodialysis patients. Methods: Forty‐six stable hemodialysis patients were randomized to receive biscuits containing 20 g/day during the first four weeks and 25 g/day in the next four weeks of either HAM‐RS2 or wheat‐flour. Fasting predialysis blood samples obtained before, during and at the end of trial were processed for biomarkers of oxidative stress and inflammation. Findings: There was no significant difference in baseline clinical or biochemical parameters between the two groups. Serum levels of TNF‐α, IL‐6, and malondialdehyde declined significantly (P &lt; 0.05) in the HAM‐RS2‐treated group but remained unchanged in the placebo‐treated group. No significant difference was observed in serum Interleukin‐1β (IL‐1β) and hs‐CRP concentrations and total antioxidant activity between two groups. Serum urea and creatinine concentrations significantly declined and severity of constipation improved in HAM‐RS2‐treated patients (P &lt; 0.05). HAM‐RS2 consumption was well tolerated and did not cause discernible side effects. Discussion: Administration of HAM‐RS2 for eight weeks significantly reduced levels of inflammatory and oxidative markers in hemodialysis patients confirming the results observed in CKD animals. 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Recent studies demonstrated that consumption of a diet enriched with amylose (HAM‐RS2), attenuates oxidative stress and inflammation, and improves intestinal microbiome in CKD rats. The present study was designed to explore the effect of dietary amylose supplementation in hemodialysis patients. Methods: Forty‐six stable hemodialysis patients were randomized to receive biscuits containing 20 g/day during the first four weeks and 25 g/day in the next four weeks of either HAM‐RS2 or wheat‐flour. Fasting predialysis blood samples obtained before, during and at the end of trial were processed for biomarkers of oxidative stress and inflammation. Findings: There was no significant difference in baseline clinical or biochemical parameters between the two groups. Serum levels of TNF‐α, IL‐6, and malondialdehyde declined significantly (P &lt; 0.05) in the HAM‐RS2‐treated group but remained unchanged in the placebo‐treated group. No significant difference was observed in serum Interleukin‐1β (IL‐1β) and hs‐CRP concentrations and total antioxidant activity between two groups. Serum urea and creatinine concentrations significantly declined and severity of constipation improved in HAM‐RS2‐treated patients (P &lt; 0.05). HAM‐RS2 consumption was well tolerated and did not cause discernible side effects. Discussion: Administration of HAM‐RS2 for eight weeks significantly reduced levels of inflammatory and oxidative markers in hemodialysis patients confirming the results observed in CKD animals. 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Recent studies demonstrated that consumption of a diet enriched with amylose (HAM‐RS2), attenuates oxidative stress and inflammation, and improves intestinal microbiome in CKD rats. The present study was designed to explore the effect of dietary amylose supplementation in hemodialysis patients. Methods: Forty‐six stable hemodialysis patients were randomized to receive biscuits containing 20 g/day during the first four weeks and 25 g/day in the next four weeks of either HAM‐RS2 or wheat‐flour. Fasting predialysis blood samples obtained before, during and at the end of trial were processed for biomarkers of oxidative stress and inflammation. Findings: There was no significant difference in baseline clinical or biochemical parameters between the two groups. Serum levels of TNF‐α, IL‐6, and malondialdehyde declined significantly (P &lt; 0.05) in the HAM‐RS2‐treated group but remained unchanged in the placebo‐treated group. No significant difference was observed in serum Interleukin‐1β (IL‐1β) and hs‐CRP concentrations and total antioxidant activity between two groups. Serum urea and creatinine concentrations significantly declined and severity of constipation improved in HAM‐RS2‐treated patients (P &lt; 0.05). HAM‐RS2 consumption was well tolerated and did not cause discernible side effects. Discussion: Administration of HAM‐RS2 for eight weeks significantly reduced levels of inflammatory and oxidative markers in hemodialysis patients confirming the results observed in CKD animals. Long term trials are needed to explore the impact of HAM‐RS2 supplementation on clinical outcomes in end stage renal disease population.</abstract><cop>Canada</cop><pmid>29532981</pmid><doi>10.1111/hdi.12653</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
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subjects Amylose - metabolism
Animals
Biomarkers - chemistry
Double-Blind Method
End stage renal disease
Female
hemodialysis
high maize resistant starch2
Humans
Inflammation - metabolism
inflammatory marker
Kidney Failure, Chronic - drug therapy
Kidney Failure, Chronic - pathology
Male
Middle Aged
oxidative markers
Oxidative Stress - physiology
Rats
Renal Dialysis - methods
Starch - metabolism
title Effect of high amylose resistant starch (HAM‐RS2) supplementation on biomarkers of inflammation and oxidative stress in hemodialysis patients: a randomized clinical trial
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