Exhaled NO as a predictor of exercise-induced asthma in cold air

Physical activity is an important part of life, and exercise-induced asthma (EIA) can reduce the quality of life. A standardized exercise challenge is needed to diagnose EIA, but this is a time consuming, effortful and expensive method. Exhaled nitric oxide (eNO) as a marker of eosinophil inflammati...

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Veröffentlicht in:Nitric oxide 2018-06, Vol.76, p.45-52
Hauptverfasser: Dreßler, Melanie, Salzmann-Manrique, Emilia, Zielen, Stefan, Schulze, Johannes
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Sprache:eng
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Zusammenfassung:Physical activity is an important part of life, and exercise-induced asthma (EIA) can reduce the quality of life. A standardized exercise challenge is needed to diagnose EIA, but this is a time consuming, effortful and expensive method. Exhaled nitric oxide (eNO) as a marker of eosinophil inflammation is determined rapidly and easily. The aim of this study was to investigate eNO as surrogate marker for predicting a positive reaction in an exercise challenge in a cold chamber (ECC). A total of 143 subjects aged 6–45 years with suspected EIA were recruited for the study. The subjects underwent an eNO measurement, an ECC and a skin prick test (SPT). To define the sensitivity and specificity of eNO as predictor, a receiver-operating characteristic (ROC) curve was plotted. The individual probability of the occurrence of a positive reaction after ECC based on an eNO value was calculated using a logistic regression model. An eNO cut-off value of 18.5 ppb (area under the curve (AUC) 0.71, p 
ISSN:1089-8603
1089-8611
DOI:10.1016/j.niox.2018.03.004