Association of vitamin D status with multiple sclerosis in a case-control study from Morocco

Growing evidence suggests that hypovitaminosis D contributes to the pathogenesis of multiple sclerosis (MS). This study aimed to evaluate whether vitamin D levels are associated with having MS and some of its characteristics in the Moroccan population. Using liquid chromatography-tandem mass spectrometry, the 25(OH)D3 metabolite was measured to quantify vitamin D serum levels (DSLs) in 113 patients with MS and 146 healthy controls matched for gender and age. DSLs were then compared between patients and controls, with correlations sought between DSLs and gender, age at onset, disease duration, MS type, degree of disability (EDSS score) and disease severity (MSSS) in patients. Hypovitaminosis D (DSL