The Relationship Between 6 Polymorphisms of Caveolin-1 Gene and the Risk of Breast Cancer

Breast cancer is the most common cancer in Iranian women. Caveolin-1 is an integral membrane protein that has a role in cellular growth. The genetic changes might affect the function of the gene and play a role in initiation or progression of breast cancer. Our results showed that polymorphisms of caveolin-1 and obesity might be associated with breast cancer. Caveolae play a role in cell signal transduction, kinetic regulation of transport vesicles, and cellular physiology. In this study, we evaluated the role of caveolin-1 (CAV-1) genotypes in the risk of breast cancer. We evaluated 6 single nucleotide polymorphisms of the CAV-1 gene in a sample size of 406 participants. Six polymorphisms—G32124A (rs3807992), T29107A (rs7804372), T28608A (rs3757733), G21985A (rs12672038), G14713A (rs3807987), and C521A (rs1997623)—were assessed using restriction fragment length polymorphism polymerase chain reaction. Regarding the distribution of genotypes, the relationship between cases and controls was significant for T29107A, G21985A, G14713A, and C521A polymorphisms, among which only C521A showed a significant difference in body mass index between the 2 groups. Moreover, the age of the 2 groups was significant in the case of G32124A and T28608A polymorphisms. Our results showed that genetic changes of CAV-1 might modify the risk for breast cancer and point out the importance of more studies for variants of this gene in breast cancer.