Noninvasive pulmonary arterial pressure estimation using a logistic-based systolic model

A hemodynamic relationship of pulmonary artery pressure (PAP) to pulmonary acceleration time (PAcT) has not yet been explicitly presented. We employed a logistic-based systolic model with a subtle modification for pulmonary circulation and provided a logical ground for the relationship between systolic PAP and PAcT using transthoracic echocardiography. Additionally, the logistic-based PAP estimation equation was deduced from the model to relate systolic PAP and PAcT. This equation was statistically tested in comparison to existing PAP estimation equations. Results showed that the logistic-based PAP estimation equation was at least as accurate as previous equations with respect to previously published mean PAP versus PAcT values. After the subtle pulmonary modification of the model, the pulmonary blood flow velocity and pressure not only well reflected the underlying pulmonary circulation physiology, but could also be presented in harmony with systemic circulation physiology. A future clinical study with actual systolic PAP versus PAcT measurements is needed to test the application of the logistic-based PAP estimation equation. After adding an amplifier for the pulmonary circulation, the simulated result of the logistic-based systolic model has been related to the observed measurement of mammals, in order to establish the relationship between systolic PAP and PAcT and to propose the logistic-based PAP estimation equation. [Display omitted] •Systolic pulmonary artery pressure (PAP) and pulmonary acceleration time (PAcT) were related based on a hemodynamic model.•The logistic-based PAP estimation equation was deduced from the model, to predict systolic PAP from the PAcT measurement.•The proposed equation was at least as accurate as previous equations with respect to mean PAP versus PAcT values.