Cigarette smoking and glutathione S-transferase M1 polymorphism associated with risk for uterine cervical cancer

Aim: To elucidate the role of tobacco smoking and polymorphisms of carcinogen metabolism genes in cervical carcinogenesis. Methods: We analyzed genotypes of nine genes, 11 polymorphisms encoding carcinogen metabolizing enzymes, information on smoking, and the presence of human papillomavirus in 12...

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Veröffentlicht in:	The journal of obstetrics and gynaecology research 2008-12, Vol.34 (6), p.994-1001
Hauptverfasser:	Nishino, Koji, Sekine, Masayuki, Kodama, Shoji, Sudo, Norihito, Aoki, Yoichi, Seki, Nao, Tanaka, Kenichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cocarcinogenesis Female glutathione S-transferase M1 Glutathione Transferase - genetics human papilloma virus Human papillomavirus Humans Middle Aged Neoplasms, Squamous Cell - enzymology Neoplasms, Squamous Cell - etiology Neoplasms, Squamous Cell - genetics Neoplasms, Squamous Cell - virology Papillomaviridae - growth & development Papillomavirus Infections - virology polymorphism Polymorphism, Genetic smoking Smoking - adverse effects Smoking - genetics uterine cervical cancer Uterine Cervical Neoplasms - enzymology Uterine Cervical Neoplasms - etiology Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - virology
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Zusammenfassung:	Aim: To elucidate the role of tobacco smoking and polymorphisms of carcinogen metabolism genes in cervical carcinogenesis. Methods: We analyzed genotypes of nine genes, 11 polymorphisms encoding carcinogen metabolizing enzymes, information on smoking, and the presence of human papillomavirus in 124 Japanese cervical cancer patients and 125 healthy controls. Results: The incidence of human papillomavirus infection (95.5% vs 9.9%; P
ISSN:	1341-8076 1447-0756
DOI:	10.1111/j.1447-0756.2008.00798.x