Pyrizomicin A and B: structure and bioactivity of new thiazolyl pyridines from Lechevalieria aerocolonigenes K10-0216

Two new antibiotics, designated pyrizomicin A and B, were isolated from the cultured broth of a rare actinomycete strain, Lechevalieria aerocolonigenes K10-0216, by silica gel and HPLC purification. The chemical structures of pyrizomicin A and B were elucidated as new thiazolyl pyridine compounds by...

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Veröffentlicht in:	Journal of antibiotics 2018-06, Vol.71 (6), p.606-608
Hauptverfasser:	Kimura, Tōru, Inahashi, Yuki, Matsuo, Hirotaka, Suga, Takuya, Iwatsuki, Masato, Shiomi, Kazuro, Takahashi, Yōko, Ōmura, Satoshi, Nakashima, Takuji
Format:	Artikel
Sprache:	eng
Schlagworte:	101/58 631/154/1435 631/326/2522 Actinobacteria - chemistry Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotics Antifungal Agents - chemistry Antifungal Agents - pharmacology Bacteria - drug effects Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Brief Communication Fungi - drug effects Life Sciences Liquid chromatography Magnetic Resonance Spectroscopy Mass spectrometry Medicinal Chemistry Microbial Sensitivity Tests Microbiology Molecular Conformation NMR Nuclear magnetic resonance Organic Chemistry Pyridines Pyridines - chemistry Pyridines - pharmacology Silica Thiazoles - chemistry Thiazoles - pharmacology
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Beschreibung
Zusammenfassung:	Two new antibiotics, designated pyrizomicin A and B, were isolated from the cultured broth of a rare actinomycete strain, Lechevalieria aerocolonigenes K10-0216, by silica gel and HPLC purification. The chemical structures of pyrizomicin A and B were elucidated as new thiazolyl pyridine compounds by nuclear magnetic resonance and mass spectrometry. Pyrizomicin A and B both showed antimicrobial activity.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/s41429-018-0038-y