Structure and biosynthesis of mayamycin B, a new polyketide with antibacterial activity from Streptomyces sp. 120454

Mayamycin B, a new antibacterial type II polyketide, together with its known congener mayamycin A, were isolated from Streptomyces sp. 120454. The structure of new compound was elucidated by extensive spectroscopic analysis and comparison with literature data. Sequencing and bioinformatics analysis...

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Veröffentlicht in:	Journal of antibiotics 2018-06, Vol.71 (6), p.601-605
Hauptverfasser:	Bo, Sheng Tao, Xu, Zi Fei, Yang, Li, Cheng, Ping, Tan, Ren Xiang, Jiao, Rui Hua, Ge, Hui Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/22/1290 692/308/153 Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology Bacteriology Bioinformatics Biomedical and Life Sciences Bioorganic Chemistry Biosynthesis Brief Communication Computational Biology Genes, Bacterial - genetics Life Sciences Magnetic Resonance Spectroscopy Medicinal Chemistry Microbiology Organic Chemistry Polyketide Synthases Polyketides - chemical synthesis Polyketides - pharmacology Streptomyces - chemistry Streptomyces - genetics Streptomyces - metabolism
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Beschreibung
Zusammenfassung:	Mayamycin B, a new antibacterial type II polyketide, together with its known congener mayamycin A, were isolated from Streptomyces sp. 120454. The structure of new compound was elucidated by extensive spectroscopic analysis and comparison with literature data. Sequencing and bioinformatics analysis revealed the biosynthetic gene cluster for mayamycins A and B.
ISSN:	0021-8820 1881-1469
DOI:	10.1038/s41429-018-0039-x