Sirenomelia and cyclopia cluster in Cali, Colombia

Sirenomelia and cyclopia cluster in Cali, Colombia

Sirenomelia and cyclopia share etiologic and pathogenic characteristics. A cluster of these two patterns of malformation in the city of Cali, Colombia, is described. Four sirenomelia and four cyclopia cases were born within a 165 days period in one hospital in Cali. The lapse between conception date...

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Veröffentlicht in:American journal of medical genetics. Part A 2008-10, Vol.146A (20), p.2626-2636
Hauptverfasser: Castilla, Eduardo E., Mastroiacovo, Pierpaolo, López-Camelo, Jorge S., Saldarriaga, Wilmar, Isaza, Carolina, Orioli, Iêda M.
Format: Artikel
Sprache:eng
Schlagworte:
Abnormalities, Multiple - epidemiology
Abnormalities, Multiple - etiology
Abnormalities, Multiple - pathology
Adult
Anus, Imperforate - etiology
Anus, Imperforate - pathology
Cali
Cleft Palate - etiology
Cleft Palate - pathology
Cluster Analysis
clusters
Colombia - epidemiology
cyclopia
ECLAMC
Ectromelia - epidemiology
Ectromelia - etiology
Ectromelia - pathology
Esophageal Atresia - etiology
Esophageal Atresia - pathology
Eye Abnormalities - epidemiology
Eye Abnormalities - etiology
Eye Abnormalities - pathology
Female
Humans
Infant, Newborn
Male
Maternal Exposure
Metals, Heavy - analysis
Pregnancy
Residence Characteristics
sirenomelia
South America
Stillbirth
Surveys and Questionnaires
Time Factors
Water Pollutants, Chemical
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Beschreibung
Zusammenfassung:Sirenomelia and cyclopia share etiologic and pathogenic characteristics. A cluster of these two patterns of malformation in the city of Cali, Colombia, is described. Four sirenomelia and four cyclopia cases were born within a 165 days period in one hospital in Cali. The lapse between conception dates of first and last cases was shorter for sirenomelia (53 days) than for cyclopia (231 days). Based on ECLAMC (Latin American Collaborative Study of Congenital Malformations) published data, the observed/expected ratio (5.7) for both defects is statistically significant (P 
ISSN:1552-4825
1552-4833
DOI:10.1002/ajmg.a.32506