Binary weight-of-evidence evaluations of chemical interactions—15 years of experience

Binary weight-of-evidence evaluations of chemical interactions—15 years of experience

The paper reflects on the last 15 years of experience in the field of mixtures risk assessment. It summarizes results found in various documents developed by the Agency for Toxic Substances and Disease Registry (ATSDR) of the weight-of-evidence (WOE) approach applied to 380 binary combinations of ch...

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Veröffentlicht in:Regulatory toxicology and pharmacology 2009-08, Vol.54 (3), p.264-271
Hauptverfasser: Pohl, Hana R., Mumtaz, Moiz M., Scinicariello, Franco, Hansen, Hugh
Format: Artikel
Sprache:eng
Schlagworte:
Additivity
Antagonism
Chemical mixtures
Dose-Response Relationship, Drug
Drug Interactions
Hazardous Substances - classification
Hazardous Substances - toxicity
Humans
Interactions
Risk Assessment
Synergism
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Zusammenfassung:The paper reflects on the last 15 years of experience in the field of mixtures risk assessment. It summarizes results found in various documents developed by the Agency for Toxic Substances and Disease Registry (ATSDR) of the weight-of-evidence (WOE) approach applied to 380 binary combinations of chemicals. Of these evaluations, 156 assessments indicated possible additivity of effects [=], 76 indicated synergism (greater-than-additive effects [>]), and 57 indicated antagonism (less-than-additive effects [
ISSN:0273-2300
1096-0295
DOI:10.1016/j.yrtph.2009.05.003