A single liquid chromatography–quadrupole time‐of‐flight mass spectrometric method for the quantification of total antibody, antibody‐conjugated drug and free payload of antibody–drug conjugates

A single hybrid affinity‐captured‐LC‐TOF‐MS/MS method was developed and applied for the quantification of total antibody, antibody conjugated drug and free payload of antibody drug conjugate (ADC). Adcetris®, a valine–citrulline monomethyl auristatin E conjugated ADC, was used as a model ADC compoun...

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Veröffentlicht in:	Biomedical chromatography 2018-07, Vol.32 (7), p.e4229-n/a
Hauptverfasser:	Byeon, Jin‐Ju, Park, Min‐Ho, Shin, Seok‐Ho, Lee, Byeong ill, Park, Yuri, Choi, Jangmi, Kim, Nahye, Kang, Yeonjae, Shin, Young G.
Format:	Artikel
Sprache:	eng
Schlagworte:	a single LC‐ESI‐TOF/MS platform ADC Adcetris quantification valine‐citrulline linker
Online-Zugang:	Volltext
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