Cancer immunotherapy in mice and humans: personal observations

An experiment involving active immunotherapy of leukemia in mice and its extension to human patients with chronic lymphocytic leukemia is described. First, anticancer activation of the immune system, how it is achieved, and observations of the central blockade of the immune system in leukemia are di...

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Veröffentlicht in:	Folia histochemica et cytobiologica 2018-01, Vol.56 (1), p.1-10
1. Verfasser:	Kawiak, Jerzy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Apoptosis Biomedical engineering Cancer Cancer immunotherapy Cancer therapies Cell activation Chemotherapy Chronic lymphocytic leukemia Colorectal cancer Experiments FDA approval Histology Hypotheses Immune checkpoint Immune response Immune system Immunology Immunotherapy Leukemia Ligands Lung cancer Lymphatic leukemia Lymphocytes Lymphoma Metastasis Mice Thymus gland Vaccines
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Beschreibung
Zusammenfassung:	An experiment involving active immunotherapy of leukemia in mice and its extension to human patients with chronic lymphocytic leukemia is described. First, anticancer activation of the immune system, how it is achieved, and observations of the central blockade of the immune system in leukemia are discussed. Clinical results of antileukemia immune activation are then presented, along with a description of new attempts to remove the immune checkpoint blockade. Personal observations are presented on possible further steps to achieving more effective active immunotherapy of cancer.
ISSN:	0239-8508 1897-5631
DOI:	10.5603/FHC.a2018.0002