Survival of Mesenchymal Stem Cells in Different Methods of Nebulization

We compared survival of bone marrow mesenchymal stem cells after compressor, ultrasound, and mesh nebulization of the cell suspension over 10 min. Viability of stromal cells was best preserved after compressor nebulization (72%). Cell survival after ultrasonic nebulization was significantly lower (2...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2018-03, Vol.164 (4), p.576-578
Hauptverfasser:	Aver’yanov, A. V., Konoplyannikov, A. G., Antonov, N. S., Osipova, G. L., Vasil’eva, O. S., Sakharova, M. G., Tatarskii, A. R., Kobylyansky, V. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Biomedical and Life Sciences Biomedicine Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - physiology Cell Biology Cell Survival Cell- and Tissue-Based Therapy - instrumentation Cell- and Tissue-Based Therapy - methods Cystic fibrosis Filtration Humans Infusion Pumps Internal Medicine Laboratory Medicine Lung cancer Mesenchymal stem cells Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - physiology Mesenchyme Methods Nebulizers and Vaporizers Pathology Pressure Respiratory tract Skin & tissue grafts Stem cells Stromal cells Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine) Ultrasonic Waves Ultrasound
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Zusammenfassung:	We compared survival of bone marrow mesenchymal stem cells after compressor, ultrasound, and mesh nebulization of the cell suspension over 10 min. Viability of stromal cells was best preserved after compressor nebulization (72%). Cell survival after ultrasonic nebulization was significantly lower (20%). After mesh nebulization, no live cells were found. Thus, compressor nebulization is the most preferable method of the production of cell aerosol for their delivery to the lower respiratory tract.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-018-4034-9