Two steps forward for myelin repair in multiple sclerosis

[...]to improve outcomes for patients with multiple sclerosis-particularly progressive multiple sclerosis-multipronged, combination therapies are probably needed.[...]to robust and predictable remyelination in rodent models,2 myelin regeneration in people with multiple sclerosis is highly variable,3...

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Veröffentlicht in:Lancet neurology 2018-04, Vol.17 (4), p.297-298
Hauptverfasser: Caprariello, Andrew V, Stys, Peter K
Format: Artikel
Sprache:eng
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Zusammenfassung:[...]to improve outcomes for patients with multiple sclerosis-particularly progressive multiple sclerosis-multipronged, combination therapies are probably needed.[...]to robust and predictable remyelination in rodent models,2 myelin regeneration in people with multiple sclerosis is highly variable,3 confounding the translation of promising interventions to the clinic.[...]myelin protein synthesis continueS into early adulthood, even after developmental myelination is presumed to be complete.
ISSN:1474-4422
1474-4465
DOI:10.1016/S1474-4422(18)30070-X