Effect of Age on Cerebral Arteriovenous Malformation Draining Vein Stenosis

The pathogenesis of venous intimal hyperplasia and venous outflow stenosis associated with cerebral arteriovenous malformation (AVM) draining veins is poorly understood. We sought to determine the relationship between venous stenosis and age. All patients with an AVM seen at our institution between 1990 and 2016 who underwent a diagnostic cerebral angiogram were retrospectively reviewed. Draining vein stenosis was measured from angiograms before any treatment. The relationship between venous stenosis and age was assessed. We included 281 patients (mean age 39 years, age range 3–83 years, 55% male). Venous stenosis measuring ≥50% was present in 59 patients (21% of cohort). Peak age at presentation was 25–29 years, whereas peak frequency of venous stenosis ≥50% was 50–54 years. Venous stenosis was present in a significantly higher proportion of patients ≥50 years versus