Bioactive metabolites of the marine actinobacterium Streptomyces sp. KMM 7210

Bioactive metabolites of the marine actinobacterium Streptomyces sp. KMM 7210

New 3-(4-hydroxybenzyl)piperazine-2,5-dione, together with the known N-[2-(4-hydroxy-phenyl)ethyl]acetamide (N-acetyltyramine), was isolated for the first time from the marine actinobacterium Streptomyces sp. The chemical structures of these compounds were determined by NMR spectroscopy and mass spe...

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Veröffentlicht in:Russian chemical bulletin 2007-04, Vol.56 (4), p.838-840
Hauptverfasser: Sobolevskaya, M. P., Denisenko, V. A., Moiseenko, A. S., Shevchenko, L. S., Menzorova, N. I., Sibirtsev, Yu. T., Kim, N. Yu, Kuznetsova, T. A.
Format: Artikel
Sprache:eng
Schlagworte:
Echinoidea
Streptomyces
Strongylocentrotus intermedius
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Zusammenfassung:New 3-(4-hydroxybenzyl)piperazine-2,5-dione, together with the known N-[2-(4-hydroxy-phenyl)ethyl]acetamide (N-acetyltyramine), was isolated for the first time from the marine actinobacterium Streptomyces sp. The chemical structures of these compounds were determined by NMR spectroscopy and mass spectrometry. The cytotoxic activities of the compounds were estimated from their effects on sperm and eggs of the sea urchin Strongylocentrotus intermedius.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-007-0126-9