Microarray Analysis on Odontogenesis-related-genes in Mouse Dental Papillae

In the present study, we examined to identify down-regulated genes between pre- and post dental papillae by microarray analysis in order to identify genes involved in tooth morphogenesis. The dental papilla tissues obtained from E16, E18, P03 and P10 of ICR mice were used for microarray analysis. Microarray analysis showed that the number of up-regulated genes ranged from 860 to 2214 from E16 to P10 and was decreased following the tooth morphogenesis. On the other hand, the number of down-regulated genes ranged from 1337 to 2924, and number of down-regulated genes was the highest (2924 genes) during E18 and P3. The results suggest that the reduced or disappeared genes in dental papilla between P0 and P3 are associated with forming and calcifying the dentin of tooth crown and regeneration of tooth.