Relations Among Foveal Blood Flow, Retinal-Choroidal Structure, and Visual Function in Retinitis Pigmentosa
To investigate the relationships between foveal blood flow as measured by laser speckle flowgraphy (LSFG), the retinal-choroidal structure in enhanced depth imaging-optical coherence tomography (EDI-OCT), and central visual function in patients with retinitis pigmentosa (RP). We studied 52 consecuti...
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Veröffentlicht in: | Investigative ophthalmology & visual science 2018-02, Vol.59 (2), p.1134-1143 |
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creator | Murakami, Yusuke Funatsu, Jun Nakatake, Shunji Fujiwara, Kohta Tachibana, Takashi Koyanagi, Yoshito Hisatomi, Toshio Yoshida, Shigeo Sonoda, Shozo Sakamoto, Taiji Sonoda, Koh-Hei Ikeda, Yasuhiro |
description | To investigate the relationships between foveal blood flow as measured by laser speckle flowgraphy (LSFG), the retinal-choroidal structure in enhanced depth imaging-optical coherence tomography (EDI-OCT), and central visual function in patients with retinitis pigmentosa (RP).
We studied 52 consecutive typical RP patients ≤50 years old and 21 age- and sex-matched controls. The mean blur rate (MBR), which represents the blood flow volume, was calculated in a 2.4-mm2 area centered on the fovea by LSFG. Subfoveal horizontal EDI-OCT images were recorded, and the choroidal area, choroidal hyporeflective area, and choroidal hyperreflective area were analyzed in the central 2.4-mm-wide region. The central foveal thickness (CFT), subfoveal choroidal thickness (SCT), and ellipsoid zone (EZ) width were also measured. Visual acuity (VA) and retinal sensitivity (Humphrey 10-2 program) were measured in the RP patients.
The MBR, choroidal area, hyporeflective area, hyperreflective area, and SCT were significantly decreased in the RP patients (all P < 0.001, versus controls). Spearman's rank testing demonstrated no significant correlation between the MBR and the choroidal structural parameters in the RP patients. Decreased MBR was significantly associated with reductions in VA, retinal sensitivity, CFT, and EZ width (all P < 0.05). The choroidal structural parameters did not correlate with central visual function, and the choroidal area, hyperreflective area, and SCT were inversely associated with CFT (all P < 0.05).
These results demonstrated the divergence between the choroidal structure and blood function, and suggest that decreased choroidal flow, rather than the structural alteration, is closely associated with foveal degeneration in RP. |
doi_str_mv | 10.1167/iovs.17-23050 |
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We studied 52 consecutive typical RP patients ≤50 years old and 21 age- and sex-matched controls. The mean blur rate (MBR), which represents the blood flow volume, was calculated in a 2.4-mm2 area centered on the fovea by LSFG. Subfoveal horizontal EDI-OCT images were recorded, and the choroidal area, choroidal hyporeflective area, and choroidal hyperreflective area were analyzed in the central 2.4-mm-wide region. The central foveal thickness (CFT), subfoveal choroidal thickness (SCT), and ellipsoid zone (EZ) width were also measured. Visual acuity (VA) and retinal sensitivity (Humphrey 10-2 program) were measured in the RP patients.
The MBR, choroidal area, hyporeflective area, hyperreflective area, and SCT were significantly decreased in the RP patients (all P < 0.001, versus controls). Spearman's rank testing demonstrated no significant correlation between the MBR and the choroidal structural parameters in the RP patients. Decreased MBR was significantly associated with reductions in VA, retinal sensitivity, CFT, and EZ width (all P < 0.05). The choroidal structural parameters did not correlate with central visual function, and the choroidal area, hyperreflective area, and SCT were inversely associated with CFT (all P < 0.05).
These results demonstrated the divergence between the choroidal structure and blood function, and suggest that decreased choroidal flow, rather than the structural alteration, is closely associated with foveal degeneration in RP.</description><identifier>ISSN: 1552-5783</identifier><identifier>EISSN: 1552-5783</identifier><identifier>DOI: 10.1167/iovs.17-23050</identifier><identifier>PMID: 29490351</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Blood Flow Velocity - physiology ; Choroid - pathology ; Female ; Fovea Centralis - blood supply ; Humans ; Laser-Doppler Flowmetry ; Male ; Middle Aged ; Regional Blood Flow - physiology ; Retina - pathology ; Retinitis Pigmentosa - diagnosis ; Retinitis Pigmentosa - physiopathology ; Tomography, Optical Coherence ; Visual Acuity - physiology ; Visual Field Tests ; Young Adult</subject><ispartof>Investigative ophthalmology & visual science, 2018-02, Vol.59 (2), p.1134-1143</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-bc44320d626c3ec9d6f38ea715e77f26deff95a0c15d9d111b97590938f730433</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29490351$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murakami, Yusuke</creatorcontrib><creatorcontrib>Funatsu, Jun</creatorcontrib><creatorcontrib>Nakatake, Shunji</creatorcontrib><creatorcontrib>Fujiwara, Kohta</creatorcontrib><creatorcontrib>Tachibana, Takashi</creatorcontrib><creatorcontrib>Koyanagi, Yoshito</creatorcontrib><creatorcontrib>Hisatomi, Toshio</creatorcontrib><creatorcontrib>Yoshida, Shigeo</creatorcontrib><creatorcontrib>Sonoda, Shozo</creatorcontrib><creatorcontrib>Sakamoto, Taiji</creatorcontrib><creatorcontrib>Sonoda, Koh-Hei</creatorcontrib><creatorcontrib>Ikeda, Yasuhiro</creatorcontrib><title>Relations Among Foveal Blood Flow, Retinal-Choroidal Structure, and Visual Function in Retinitis Pigmentosa</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>To investigate the relationships between foveal blood flow as measured by laser speckle flowgraphy (LSFG), the retinal-choroidal structure in enhanced depth imaging-optical coherence tomography (EDI-OCT), and central visual function in patients with retinitis pigmentosa (RP).
We studied 52 consecutive typical RP patients ≤50 years old and 21 age- and sex-matched controls. The mean blur rate (MBR), which represents the blood flow volume, was calculated in a 2.4-mm2 area centered on the fovea by LSFG. Subfoveal horizontal EDI-OCT images were recorded, and the choroidal area, choroidal hyporeflective area, and choroidal hyperreflective area were analyzed in the central 2.4-mm-wide region. The central foveal thickness (CFT), subfoveal choroidal thickness (SCT), and ellipsoid zone (EZ) width were also measured. Visual acuity (VA) and retinal sensitivity (Humphrey 10-2 program) were measured in the RP patients.
The MBR, choroidal area, hyporeflective area, hyperreflective area, and SCT were significantly decreased in the RP patients (all P < 0.001, versus controls). Spearman's rank testing demonstrated no significant correlation between the MBR and the choroidal structural parameters in the RP patients. Decreased MBR was significantly associated with reductions in VA, retinal sensitivity, CFT, and EZ width (all P < 0.05). The choroidal structural parameters did not correlate with central visual function, and the choroidal area, hyperreflective area, and SCT were inversely associated with CFT (all P < 0.05).
These results demonstrated the divergence between the choroidal structure and blood function, and suggest that decreased choroidal flow, rather than the structural alteration, is closely associated with foveal degeneration in RP.</description><subject>Adult</subject><subject>Blood Flow Velocity - physiology</subject><subject>Choroid - pathology</subject><subject>Female</subject><subject>Fovea Centralis - blood supply</subject><subject>Humans</subject><subject>Laser-Doppler Flowmetry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Regional Blood Flow - physiology</subject><subject>Retina - pathology</subject><subject>Retinitis Pigmentosa - diagnosis</subject><subject>Retinitis Pigmentosa - physiopathology</subject><subject>Tomography, Optical Coherence</subject><subject>Visual Acuity - physiology</subject><subject>Visual Field Tests</subject><subject>Young Adult</subject><issn>1552-5783</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDtPwzAURi0EoqUwsiKPDE3xI47jsVQEkJBA5bFaru0UgxOXOCni35PSgpju1f3O_YYDwClGE4wzfuHCOk4wTwhFDO2BIWaMJIzndP_fPgBHMb4hRDAm6BAMiEgFogwPwfvcetW6UEc4rUK9hEVYW-XhpQ_BwMKHzzGc29bVyiez19AEZ_r0sW063XaNHUNVG_jiYtdfi67Wmyro6u2Pa12ED25Z2boNUR2Dg1L5aE92cwSei6un2U1yd399O5veJZqKvE0WOk0pQSYjmaZWC5OVNLeKY2Y5L0lmbFkKppDGzAiDMV4IzgQSNC85RSmlI3C-7V014aOzsZWVi9p6r2obuigJQoJlgqeoR5MtqpsQY2NLuWpcpZoviZHc-JUbvxJz-eO358921d2isuaP_hVKvwG8V3cB</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Murakami, Yusuke</creator><creator>Funatsu, Jun</creator><creator>Nakatake, Shunji</creator><creator>Fujiwara, Kohta</creator><creator>Tachibana, Takashi</creator><creator>Koyanagi, Yoshito</creator><creator>Hisatomi, Toshio</creator><creator>Yoshida, Shigeo</creator><creator>Sonoda, Shozo</creator><creator>Sakamoto, Taiji</creator><creator>Sonoda, Koh-Hei</creator><creator>Ikeda, Yasuhiro</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180201</creationdate><title>Relations Among Foveal Blood Flow, Retinal-Choroidal Structure, and Visual Function in Retinitis Pigmentosa</title><author>Murakami, Yusuke ; Funatsu, Jun ; Nakatake, Shunji ; Fujiwara, Kohta ; Tachibana, Takashi ; Koyanagi, Yoshito ; Hisatomi, Toshio ; Yoshida, Shigeo ; Sonoda, Shozo ; Sakamoto, Taiji ; Sonoda, Koh-Hei ; Ikeda, Yasuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-bc44320d626c3ec9d6f38ea715e77f26deff95a0c15d9d111b97590938f730433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Blood Flow Velocity - physiology</topic><topic>Choroid - pathology</topic><topic>Female</topic><topic>Fovea Centralis - blood supply</topic><topic>Humans</topic><topic>Laser-Doppler Flowmetry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Regional Blood Flow - physiology</topic><topic>Retina - pathology</topic><topic>Retinitis Pigmentosa - diagnosis</topic><topic>Retinitis Pigmentosa - physiopathology</topic><topic>Tomography, Optical Coherence</topic><topic>Visual Acuity - physiology</topic><topic>Visual Field Tests</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murakami, Yusuke</creatorcontrib><creatorcontrib>Funatsu, Jun</creatorcontrib><creatorcontrib>Nakatake, Shunji</creatorcontrib><creatorcontrib>Fujiwara, Kohta</creatorcontrib><creatorcontrib>Tachibana, Takashi</creatorcontrib><creatorcontrib>Koyanagi, Yoshito</creatorcontrib><creatorcontrib>Hisatomi, Toshio</creatorcontrib><creatorcontrib>Yoshida, Shigeo</creatorcontrib><creatorcontrib>Sonoda, Shozo</creatorcontrib><creatorcontrib>Sakamoto, Taiji</creatorcontrib><creatorcontrib>Sonoda, Koh-Hei</creatorcontrib><creatorcontrib>Ikeda, Yasuhiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murakami, Yusuke</au><au>Funatsu, Jun</au><au>Nakatake, Shunji</au><au>Fujiwara, Kohta</au><au>Tachibana, Takashi</au><au>Koyanagi, Yoshito</au><au>Hisatomi, Toshio</au><au>Yoshida, Shigeo</au><au>Sonoda, Shozo</au><au>Sakamoto, Taiji</au><au>Sonoda, Koh-Hei</au><au>Ikeda, Yasuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relations Among Foveal Blood Flow, Retinal-Choroidal Structure, and Visual Function in Retinitis Pigmentosa</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>59</volume><issue>2</issue><spage>1134</spage><epage>1143</epage><pages>1134-1143</pages><issn>1552-5783</issn><eissn>1552-5783</eissn><abstract>To investigate the relationships between foveal blood flow as measured by laser speckle flowgraphy (LSFG), the retinal-choroidal structure in enhanced depth imaging-optical coherence tomography (EDI-OCT), and central visual function in patients with retinitis pigmentosa (RP).
We studied 52 consecutive typical RP patients ≤50 years old and 21 age- and sex-matched controls. The mean blur rate (MBR), which represents the blood flow volume, was calculated in a 2.4-mm2 area centered on the fovea by LSFG. Subfoveal horizontal EDI-OCT images were recorded, and the choroidal area, choroidal hyporeflective area, and choroidal hyperreflective area were analyzed in the central 2.4-mm-wide region. The central foveal thickness (CFT), subfoveal choroidal thickness (SCT), and ellipsoid zone (EZ) width were also measured. Visual acuity (VA) and retinal sensitivity (Humphrey 10-2 program) were measured in the RP patients.
The MBR, choroidal area, hyporeflective area, hyperreflective area, and SCT were significantly decreased in the RP patients (all P < 0.001, versus controls). Spearman's rank testing demonstrated no significant correlation between the MBR and the choroidal structural parameters in the RP patients. Decreased MBR was significantly associated with reductions in VA, retinal sensitivity, CFT, and EZ width (all P < 0.05). The choroidal structural parameters did not correlate with central visual function, and the choroidal area, hyperreflective area, and SCT were inversely associated with CFT (all P < 0.05).
These results demonstrated the divergence between the choroidal structure and blood function, and suggest that decreased choroidal flow, rather than the structural alteration, is closely associated with foveal degeneration in RP.</abstract><cop>United States</cop><pmid>29490351</pmid><doi>10.1167/iovs.17-23050</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Blood Flow Velocity - physiology Choroid - pathology Female Fovea Centralis - blood supply Humans Laser-Doppler Flowmetry Male Middle Aged Regional Blood Flow - physiology Retina - pathology Retinitis Pigmentosa - diagnosis Retinitis Pigmentosa - physiopathology Tomography, Optical Coherence Visual Acuity - physiology Visual Field Tests Young Adult |
title | Relations Among Foveal Blood Flow, Retinal-Choroidal Structure, and Visual Function in Retinitis Pigmentosa |
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