Relations Among Foveal Blood Flow, Retinal-Choroidal Structure, and Visual Function in Retinitis Pigmentosa

To investigate the relationships between foveal blood flow as measured by laser speckle flowgraphy (LSFG), the retinal-choroidal structure in enhanced depth imaging-optical coherence tomography (EDI-OCT), and central visual function in patients with retinitis pigmentosa (RP). We studied 52 consecuti...

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Veröffentlicht in:Investigative ophthalmology & visual science 2018-02, Vol.59 (2), p.1134-1143
Hauptverfasser: Murakami, Yusuke, Funatsu, Jun, Nakatake, Shunji, Fujiwara, Kohta, Tachibana, Takashi, Koyanagi, Yoshito, Hisatomi, Toshio, Yoshida, Shigeo, Sonoda, Shozo, Sakamoto, Taiji, Sonoda, Koh-Hei, Ikeda, Yasuhiro
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container_issue 2
container_start_page 1134
container_title Investigative ophthalmology & visual science
container_volume 59
creator Murakami, Yusuke
Funatsu, Jun
Nakatake, Shunji
Fujiwara, Kohta
Tachibana, Takashi
Koyanagi, Yoshito
Hisatomi, Toshio
Yoshida, Shigeo
Sonoda, Shozo
Sakamoto, Taiji
Sonoda, Koh-Hei
Ikeda, Yasuhiro
description To investigate the relationships between foveal blood flow as measured by laser speckle flowgraphy (LSFG), the retinal-choroidal structure in enhanced depth imaging-optical coherence tomography (EDI-OCT), and central visual function in patients with retinitis pigmentosa (RP). We studied 52 consecutive typical RP patients ≤50 years old and 21 age- and sex-matched controls. The mean blur rate (MBR), which represents the blood flow volume, was calculated in a 2.4-mm2 area centered on the fovea by LSFG. Subfoveal horizontal EDI-OCT images were recorded, and the choroidal area, choroidal hyporeflective area, and choroidal hyperreflective area were analyzed in the central 2.4-mm-wide region. The central foveal thickness (CFT), subfoveal choroidal thickness (SCT), and ellipsoid zone (EZ) width were also measured. Visual acuity (VA) and retinal sensitivity (Humphrey 10-2 program) were measured in the RP patients. The MBR, choroidal area, hyporeflective area, hyperreflective area, and SCT were significantly decreased in the RP patients (all P < 0.001, versus controls). Spearman's rank testing demonstrated no significant correlation between the MBR and the choroidal structural parameters in the RP patients. Decreased MBR was significantly associated with reductions in VA, retinal sensitivity, CFT, and EZ width (all P < 0.05). The choroidal structural parameters did not correlate with central visual function, and the choroidal area, hyperreflective area, and SCT were inversely associated with CFT (all P < 0.05). These results demonstrated the divergence between the choroidal structure and blood function, and suggest that decreased choroidal flow, rather than the structural alteration, is closely associated with foveal degeneration in RP.
doi_str_mv 10.1167/iovs.17-23050
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Decreased MBR was significantly associated with reductions in VA, retinal sensitivity, CFT, and EZ width (all P &lt; 0.05). The choroidal structural parameters did not correlate with central visual function, and the choroidal area, hyperreflective area, and SCT were inversely associated with CFT (all P &lt; 0.05). 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Funatsu, Jun ; Nakatake, Shunji ; Fujiwara, Kohta ; Tachibana, Takashi ; Koyanagi, Yoshito ; Hisatomi, Toshio ; Yoshida, Shigeo ; Sonoda, Shozo ; Sakamoto, Taiji ; Sonoda, Koh-Hei ; Ikeda, Yasuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-bc44320d626c3ec9d6f38ea715e77f26deff95a0c15d9d111b97590938f730433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Blood Flow Velocity - physiology</topic><topic>Choroid - pathology</topic><topic>Female</topic><topic>Fovea Centralis - blood supply</topic><topic>Humans</topic><topic>Laser-Doppler Flowmetry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Regional Blood Flow - physiology</topic><topic>Retina - pathology</topic><topic>Retinitis Pigmentosa - diagnosis</topic><topic>Retinitis Pigmentosa - physiopathology</topic><topic>Tomography, Optical Coherence</topic><topic>Visual Acuity - physiology</topic><topic>Visual Field Tests</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murakami, Yusuke</creatorcontrib><creatorcontrib>Funatsu, Jun</creatorcontrib><creatorcontrib>Nakatake, Shunji</creatorcontrib><creatorcontrib>Fujiwara, Kohta</creatorcontrib><creatorcontrib>Tachibana, Takashi</creatorcontrib><creatorcontrib>Koyanagi, Yoshito</creatorcontrib><creatorcontrib>Hisatomi, Toshio</creatorcontrib><creatorcontrib>Yoshida, Shigeo</creatorcontrib><creatorcontrib>Sonoda, Shozo</creatorcontrib><creatorcontrib>Sakamoto, Taiji</creatorcontrib><creatorcontrib>Sonoda, Koh-Hei</creatorcontrib><creatorcontrib>Ikeda, Yasuhiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology &amp; 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We studied 52 consecutive typical RP patients ≤50 years old and 21 age- and sex-matched controls. The mean blur rate (MBR), which represents the blood flow volume, was calculated in a 2.4-mm2 area centered on the fovea by LSFG. Subfoveal horizontal EDI-OCT images were recorded, and the choroidal area, choroidal hyporeflective area, and choroidal hyperreflective area were analyzed in the central 2.4-mm-wide region. The central foveal thickness (CFT), subfoveal choroidal thickness (SCT), and ellipsoid zone (EZ) width were also measured. Visual acuity (VA) and retinal sensitivity (Humphrey 10-2 program) were measured in the RP patients. The MBR, choroidal area, hyporeflective area, hyperreflective area, and SCT were significantly decreased in the RP patients (all P &lt; 0.001, versus controls). Spearman's rank testing demonstrated no significant correlation between the MBR and the choroidal structural parameters in the RP patients. 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subjects Adult
Blood Flow Velocity - physiology
Choroid - pathology
Female
Fovea Centralis - blood supply
Humans
Laser-Doppler Flowmetry
Male
Middle Aged
Regional Blood Flow - physiology
Retina - pathology
Retinitis Pigmentosa - diagnosis
Retinitis Pigmentosa - physiopathology
Tomography, Optical Coherence
Visual Acuity - physiology
Visual Field Tests
Young Adult
title Relations Among Foveal Blood Flow, Retinal-Choroidal Structure, and Visual Function in Retinitis Pigmentosa
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