Clinical Evaluation of Hepatocarcinogenesis and Outcome Using a Novel Glycobiomarker Wisteria floribunda Agglutinin-Positive Mac-2 Binding Protein (WFA+-M2BP) in Chronic Hepatitis C with Advanced Fibrosis

This study aimed to assess the association between the serum glycobiomarker Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) for liver fibrosis and outcomes and carcinogenesis of hepatocellular carcinoma (HCC) in chronic hepatitis C (CHC) patients with advanced fibrosis. Ser...

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Veröffentlicht in:	Japanese Journal of Infectious Diseases 2018, Vol.71(3), pp.177-183
Hauptverfasser:	Inoue, Takako, Tsuzuki, Yuji, Iio, Etsuko, Shinkai, Noboru, Matsunami, Kayoko, Fujiwara, Kei, Matsuura, Kentaro, Nojiri, Shunsuke, Tanaka, Yasuhito
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antigens, Neoplasm - blood Antigens, Neoplasm - chemistry Biomarkers - blood Biomarkers - chemistry Carcinogenesis Carcinogens Carcinoma, Hepatocellular - complications Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - epidemiology chronic hepatitis C (CHC) Female Fibrosis glycobiomarker Hepatitis Hepatitis C Hepatitis C, Chronic - complications Hepatitis C, Chronic - diagnosis Hepatitis C, Chronic - epidemiology hepatocarcinogenesis Hepatocellular carcinoma Humans Interferon Liver Liver Cirrhosis - complications Liver Cirrhosis - diagnosis Liver Cirrhosis - epidemiology liver fibrosis Liver Neoplasms - complications Liver Neoplasms - diagnosis Liver Neoplasms - epidemiology Male Membrane Glycoproteins - blood Membrane Glycoproteins - chemistry Middle Aged Patients Plant Lectins Proteins Receptors, N-Acetylglucosamine Survival Wisteria floribunda Wisteria floribunda agglutinin-positive-Mac-2 binding protein (WFA+-M2BP) Young Adult
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Zusammenfassung:	This study aimed to assess the association between the serum glycobiomarker Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) for liver fibrosis and outcomes and carcinogenesis of hepatocellular carcinoma (HCC) in chronic hepatitis C (CHC) patients with advanced fibrosis. Serum WFA+-M2BP levels were measured in 128 consecutive CHC patients including 49 with HCC histopathologically diagnosed with advanced fibrosis (44 with fibrosis stage F3 and 84 with fibrosis stage F4) in our hospital. The median WFA+-M2BP level was significantly higher in F4 than in F3 patients (6.9 vs. 2.3 cutoff index [COI], respectively; p
ISSN:	1344-6304 1884-2836
DOI:	10.7883/yoken.JJID.2017.459