Ionoregulatory Disruption and Acetylcholinesterase Activity in Aluminium Toxicity: Effects of Vitamins C and E

Ionoregulatory Disruption and Acetylcholinesterase Activity in Aluminium Toxicity: Effects of Vitamins C and E

To investigate the effects of vitamin C and E on electrolyte profile and the activity of acetylcholinesterase (AChE) in Aluminium (Al) chloride exposed rats, thirty-six male rats were used for this study. The animals were randomly grouped into six (n=6); group I (Control) was given normal saline. Gr...

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Veröffentlicht in:Nigerian journal of physiological sciences 2017-12, Vol.32 (2), p.207-212
Hauptverfasser: Ugbaja, R N, Olaniyan, T O, Afolabi, O K, Onunkwor, B O, Dosumu, O A, Akinhanmi, T F, Tiamiyu, A Y, Aliyu-Banjo, N O
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholinesterase
Aluminum - pharmacology
Animals
Antioxidants - pharmacology
Ascorbic Acid - pharmacology
Body Weight - drug effects
Erythrocytes - drug effects
Male
Rats
Vitamin E - pharmacology
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Zusammenfassung:To investigate the effects of vitamin C and E on electrolyte profile and the activity of acetylcholinesterase (AChE) in Aluminium (Al) chloride exposed rats, thirty-six male rats were used for this study. The animals were randomly grouped into six (n=6); group I (Control) was given normal saline. Group II (Al only) was exposed to 20mg/kg body weight (BW) of Al. Groups III (Vitamin C only) and IV (Vitamin E only) were administered 200mg/kg BW of vitamin C and vitamin E respectively. Groups V (Al + Vit C) and VI (Al + Vit E) were exposed to 20mg/kg Al and were treated with 200mg/kg vitamin C and vitamin E respectively. Al exposure resulted in a significant (P
ISSN:0794-859X