Natural Killer Cells Detect a Tumor-Produced Growth Factor: A Vestige of Antiviral Resistance?

Natural Killer Cells Detect a Tumor-Produced Growth Factor: A Vestige of Antiviral Resistance?

In addition to exogenous ligands derived from pathogens, natural killer (NK) and other innate cells can recognize endogenous ligands that often act as markers of stress or damage. A recent study reports that one of these receptors, human NKp44, recognizes PDGF-DD, providing a rare example of the rec...

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Veröffentlicht in:Trends in immunology 2018-05, Vol.39 (5), p.357-358
1. Verfasser: Trinchieri, Giorgio
Format: Artikel
Sprache:eng
Schlagworte:
Anticancer properties
Antigens
Antitumor activity
Antiviral Agents
Antiviral drugs
Cancer
Cell cycle
Cytokines
Cytotoxicity
Genes
Growth factors
Humans
Killer Cells, Natural
Ligands
Natural killer cells
Neoplasms
Physiology
Platelet-derived growth factor
Proteins
Receptors
Recognition
Tumors
Viruses
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Beschreibung
Zusammenfassung:In addition to exogenous ligands derived from pathogens, natural killer (NK) and other innate cells can recognize endogenous ligands that often act as markers of stress or damage. A recent study reports that one of these receptors, human NKp44, recognizes PDGF-DD, providing a rare example of the recognition of a soluble growth factor as a stress signal. The recognition of PDGF-DD induces the secretion of cytokines with antitumor activity.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2018.02.002