Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines

Copper-catalyzed three-component cyclization of amidines, styrenes, and fluoroalkyl halides for the synthesis of modular fluoroalkylated pyrimidines

An efficient copper-catalyzed three-component cyclization for the construction of highly functionalized pyrimidine derivatives from readily available amidines, styrenes and fluoroalkyl halides is developed. This protocol distinguishes itself by the formation of three new C-C/C-N bonds and a new six-...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (21), p.2615-2618
Hauptverfasser: Chu, Xue-Qiang, Cheng, Bu-Qing, Zhang, Yao-Wei, Ge, Danhua, Shen, Zhi-Liang, Loh, Teck-Peng
Format: Artikel
Sprache:eng
Schlagworte:
Chemical synthesis
Copper
Halides
Modular construction
Oxidation
Pyrimidines
Styrenes
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Zusammenfassung:An efficient copper-catalyzed three-component cyclization for the construction of highly functionalized pyrimidine derivatives from readily available amidines, styrenes and fluoroalkyl halides is developed. This protocol distinguishes itself by the formation of three new C-C/C-N bonds and a new six-membered ring through a radical addition/oxidation/cyclization sequence in a one-pot manner.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc09571f