Genome-Wide Association and Functional Studies Identify SCML4 and THSD7A as Novel Susceptibility Genes for Coronary Artery Disease

OBJECTIVE—The genetic contribution to coronary artery disease (CAD) remains largely unclear. We combined genetic screening with functional characterizations to identify novel loci and candidate genes for CAD. APPROACH AND RESULTS—We performed genome-wide screening followed by multicenter validation...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2018-04, Vol.38 (4), p.964-975
Hauptverfasser:	Li, Yang, Wang, Dao Wen, Chen, Yundai, Chen, Can, Guo, Jian, Zhang, Shu, Sun, Zhijun, Ding, Hu, Yao, Yan, Zhou, Lei, Xu, Ke, Song, Chun, Yang, Fan, Zhao, Bin, Yan, Han, Wang, Wen-Jing, Wu, Chong, Lu, Xiangfeng, Yang, Xueli, Dong, Jie, Zheng, Guyan, Tian, Shuhan, Cui, Yanjun, Jin, Lijuan, Liu, Gangqiong, Cui, Hanbin, Wang, Shenghuang, Jiang, Feng, Wang, Changhua, Erdmann, Jeanette, Zeng, Linyao, Huang, Shian, Zhong, Jianfeng, Ma, Yuehua, Chen, Wenjiang, Sun, Jianli, Lei, Wei, Chen, Shenghan, Rao, Shaoqi, Gu, Dongfeng, Schunkert, Heribert, Tian, Xiao-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Asian Continental Ancestry Group - genetics Carotid Arteries - metabolism Carotid Arteries - pathology Carotid Stenosis - genetics Carotid Stenosis - metabolism Carotid Stenosis - pathology Cells, Cultured China - epidemiology Coronary Artery Disease - diagnosis Coronary Artery Disease - ethnology Coronary Artery Disease - genetics Coronary Artery Disease - metabolism Coronary Vessels - metabolism Coronary Vessels - pathology Disease Models, Animal Female Gene Frequency Genetic Predisposition to Disease Genome-Wide Association Study Human Umbilical Vein Endothelial Cells - metabolism Human Umbilical Vein Endothelial Cells - pathology Humans Male Middle Aged Phenotype Polycomb-Group Proteins - genetics Polycomb-Group Proteins - metabolism Polymorphism, Single Nucleotide Rats, Sprague-Dawley Risk Factors Thrombospondins - genetics Thrombospondins - metabolism Vascular Remodeling
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Zusammenfassung:	OBJECTIVE—The genetic contribution to coronary artery disease (CAD) remains largely unclear. We combined genetic screening with functional characterizations to identify novel loci and candidate genes for CAD. APPROACH AND RESULTS—We performed genome-wide screening followed by multicenter validation in 8 cohorts consisting of 21 828 participants of Han ethnicity and identified 3 novel intragenic SNPs, rs9486729 (SCML4; odds ratio, 1.25; 95% CI, 1.17–1.34; P=3.51×10), rs17165136 (THSD7A; odds ratio 1.28; 95% CI, 1.21–1.35; P
ISSN:	1079-5642 1524-4636
DOI:	10.1161/ATVBAHA.117.310594