Human Neonatal Rotavirus Vaccine (RV3-BB) to Target Rotavirus from Birth

Severe diarrhea from rotavirus remains an important cause of illness in infants. In this trial, investigators in Indonesia assessed the potential benefit of a neonatal rotavirus vaccine.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2018-02, Vol.378 (8), p.719-730
Hauptverfasser:	Bines, Julie E, At Thobari, Jarir, Satria, Cahya Dewi, Handley, Amanda, Watts, Emma, Cowley, Daniel, Nirwati, Hera, Ackland, James, Standish, Jane, Justice, Frances, Byars, Gabrielle, Lee, Katherine J, Barnes, Graeme L, Bachtiar, Novilia S, Viska Icanervilia, Ajeng, Boniface, Karen, Bogdanovic-Sakran, Nada, Pavlic, Daniel, Bishop, Ruth F, Kirkwood, Carl D, Buttery, Jim P, Soenarto, Yati
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Age Birth Clinical trials Combined vaccines Double-Blind Method Drug dosages Feces - virology Female Gastroenteritis Gastroenteritis - epidemiology Gastroenteritis - prevention & control Gastroenteritis - virology Humans Immune response Immunization Immunization Schedule Indonesia Infant Infant, Newborn Intention to Treat Analysis Male Neonates Newborn babies Preventive medicine Rotavirus Rotavirus - isolation & purification Rotavirus Infections - prevention & control Rotavirus Vaccines - administration & dosage Rotavirus Vaccines - adverse effects Rotavirus Vaccines - immunology Treatment Outcome Vaccine efficacy Vaccines Viral infections Viruses
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Beschreibung
Zusammenfassung:	Severe diarrhea from rotavirus remains an important cause of illness in infants. In this trial, investigators in Indonesia assessed the potential benefit of a neonatal rotavirus vaccine.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1706804